Cholesteryl Ester-Rich Very Low Density Lipoproteins: Magnetic Resonance Studies

  • Joel D. Morrisett
  • Richard K. Stockton
  • Roger D. Knapp
Conference paper


A number of different animals have been used to model human atherosclerosis. Among these are the nonhuman primates, pigs, rabbits, guinea pigs, chickens, and rats. Of these animal models, the rabbit has been the most intensely- studied. Although the rabbit has a natural lesion distribution and lipid metabolism which is significantly different from that of man, this animal affords a number of unique advantages including low probability for spontaneous atherosclerosis, fast response to dietary or mechanical intervention, low cost, and facile handling. Furthermore, dietary refinements and careful drug administration have permitted the production of atherosclerotic lesions in the medium and large arteries of the rabbit which closely mimic those found in man. The types and locations of these induced lesions are now well-known. Over the past 50 years, the cholesterol-fed rabbit has been studied extensively as an experimental model for determining the relationship between dietary lipids and atherosclerosis. When the normal chow diet is enriched with 0.5-2.0% cholesterol, rabbits rapidly develop hyper- cholesterolemia (Duff 1935; Shore et al. 1974; Shumaker 1956) with subsequent appearance of atheromata (Anitschkow 1933; Kritchevsky 1954). While initially the cholesterol diet was utilized only to study induction of atherosclerotic lesions (Duff 1935), during the past 20 years a major focus of interest has been on the characterization of cholesterol-induced changes in the plasma lipoproteins.


Cholesteryl Ester Fatty Acyl Normal Chow Diet Steroid Ring Lesteryl Ester 
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Copyright information

© Springer-Verlag New York Inc. 1980

Authors and Affiliations

  • Joel D. Morrisett
  • Richard K. Stockton
  • Roger D. Knapp

There are no affiliations available

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