Cholesteryl Ester-Rich Very Low Density Lipoproteins: Magnetic Resonance Studies
A number of different animals have been used to model human atherosclerosis. Among these are the nonhuman primates, pigs, rabbits, guinea pigs, chickens, and rats. Of these animal models, the rabbit has been the most intensely- studied. Although the rabbit has a natural lesion distribution and lipid metabolism which is significantly different from that of man, this animal affords a number of unique advantages including low probability for spontaneous atherosclerosis, fast response to dietary or mechanical intervention, low cost, and facile handling. Furthermore, dietary refinements and careful drug administration have permitted the production of atherosclerotic lesions in the medium and large arteries of the rabbit which closely mimic those found in man. The types and locations of these induced lesions are now well-known. Over the past 50 years, the cholesterol-fed rabbit has been studied extensively as an experimental model for determining the relationship between dietary lipids and atherosclerosis. When the normal chow diet is enriched with 0.5-2.0% cholesterol, rabbits rapidly develop hyper- cholesterolemia (Duff 1935; Shore et al. 1974; Shumaker 1956) with subsequent appearance of atheromata (Anitschkow 1933; Kritchevsky 1954). While initially the cholesterol diet was utilized only to study induction of atherosclerotic lesions (Duff 1935), during the past 20 years a major focus of interest has been on the characterization of cholesterol-induced changes in the plasma lipoproteins.
KeywordsCholesteryl Ester Fatty Acyl Normal Chow Diet Steroid Ring Lesteryl Ester
Unable to display preview. Download preview PDF.
- Anitschko A (1933) Experimental arteriosclerosis in animals. In: Cowdry EV (ed) Arteriosclerosis. The Macmillan Company, New YorkGoogle Scholar
- Duff GL (1935) Experimental cholesterol arteriosclerosis and its relationship to human arteriosclerosis. Arch Pathol 20: 82–123, 259-304Google Scholar
- Morrisett JD, Pownall HJ, Jackson RL, Segura R, Gotto AM, Taunton OD (1977) Effects of polyunsaturated and saturated fat diets on the chemical composition and thermotropic properties of human plasma lipoproteins. In: Holman RT, Kunau W-H (eds) Polyunsaturated fatty acids, American Oil Chemists’ Society Monograph #4. AOCA Publishers, Champaign, Illinois, pp 139–161Google Scholar
- Morrisett JD, Pownall HJ, Roth RI, Gotto AM, Patsch JR (1979) Structure of rabbit cholesteryl ester-rich very low density lipoproteins (CER-VLDL). Biophys J 25: 286aGoogle Scholar
- Seelig, J (1976) Anisotropic motion in liquid crystalline structures. In: Berliner LJ (ed) Spin labeling: theory and techniques. Academic Press, Inc., New York, Chapter 10Google Scholar
- Shumaker VN (1956) Cholesterolemic rabbit lipoproteins—serum lipoproteins of cholesterolemic rabbits. Am J Physiol 184: 35–42Google Scholar
- Small DM (1970) The physical state of lipids of biological importance: cholesteryl esters, cholesterol, triglyceride. Adv Exp Med Biol 26: 55–83Google Scholar