Cholesterol Feeding: Effects on Lipoprotein Structure and Metabolism

  • Robert W. Mahley
Conference paper


The consumption of diets high in cholesterol and fat produces marked changes in plasma lipoproteins. Comparative studies of a variety of species have revealed that certain of these changes in lipoproteins are consistent among the species (for review, see Mahley 1978). Alterations in canine lipoproteins are the most dramatic changes induced in any species and highlight changes which span a spectrum of other species, including man (Mahley et al. 1974, 1975, 1976b, 1977b, 1978a; Mahley and Holcombe 1977). It is the purpose of this paper to describe the cholesterol-induced changes in canine lipoproteins and to describe how these lipoproteins interact, in vitro and in vivo, with a variety of cells which are potentially important in the development of accelerated atherosclerosis.


Smooth Muscle Cell Lysine Residue Cholesteryl Ester Plasma Lipoprotein Plasma Cholesterol Level 
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© Springer-Verlag New York Inc. 1980

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  • Robert W. Mahley

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