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Vestibular Nuclei: Neuronal Loss in Mice with Otoconial Agenesis and Evidence of Right-Left Asymmetry

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Book cover The Vestibular System: Function and Morphology

Abstract

The importance of sensory systems to brain development has been investigated in terms of transneuronal changes due to sensory deprivation. The bulk of these studies have involved the visual system, in part because of the relative ease with which the animal can be deprived of stimulation. Notably lacking in the literature are reports of the effects of vestibular deprivation. This is most unfortunate since some investigators (32) postulate the vestibular system to play a key role in brain development, whereas others have argued that vestibular deprivation may underlie some mental disorders. variety of mental disorders, most notably autism and schizophrenia, have been reported by many investigators to be associated with vestibular disorders or abnormalities (2,19,30,40,41,45,50,52,53). Further, increased vestibular stimulation has been reported to significantly ameliorate the symptoms of a number of mental and/or brain disorders (2,7,8,30,37). Thus, there are many reasons why a study of vestibular deprivation ought to be undertaken, but until recently there were no feasible ways of producing this deprivation except through surgical intervention and the attendant stress and trauma.

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Authors
  1. Geoffrey M. Clark
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  2. Robert J. Douglas
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  3. Lawrence C. Erway
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  4. David G. Hubbard
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Editors and Affiliations

  1. University of Milan Medical School, Milan, Italy

    Torquato Gualtierotti (Head, Institute of Human Physiology) (Head, Institute of Human Physiology)

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Clark, G.M., Douglas, R.J., Erway, L.C., Hubbard, D.G. (1981). Vestibular Nuclei: Neuronal Loss in Mice with Otoconial Agenesis and Evidence of Right-Left Asymmetry. In: Gualtierotti, T. (eds) The Vestibular System: Function and Morphology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5902-2_6

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  • DOI: https://doi.org/10.1007/978-1-4612-5902-2_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5904-6

  • Online ISBN: 978-1-4612-5902-2

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