Effect of Posture, Isometric Hand-Grip Exercise, and Norepinephrine Infusion in Normal-Renin Hypertensive Patients
The role of the sympathetic nervous system in the pathogenesis of clinical hypertension has remained unsettled and controversial. Development of methods for accurate and sensitive measurement of plasma catecholamine concentration offer promise in defining the role of noradrenergic and adre- nomedullary function in this regard. Since the sympathetic nervous system plays a prominent role in rapid adjustment of the circulation to such perturbations as upright posture (1) or exercise (1, 2), quantification of the role of this system requires correlation between cardiovascular events and biochemical parameters. In comparing hypertensive to normotensive subjects, interpretation of the significance of levels of endogenous plasma catecholamines must be made in light of considerable evidence for vascular hyperresponsiveness to infused catecholamines in many hypertensive subjects (3, 4).
KeywordsArterial Pressure Plasma Norepinephrine Hypertensive Subject Plasma Catecholamine Quiet Standing
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