High-Molecular-Weight Form of Renal Renin and Renin-Binding Substance in the Dog

  • Kenjiro Yamamoto
  • Fumihiko Ikemoto
  • Kazuo Takaori
  • Minoru Kawamura
Conference paper


A high-molecular-weight form of renin, has been reported to be detectable in kidney cortex (1), amniotic fluid (2), and plasma (3). However, little is known of its relevance in physiology and pathology, including the mechanism of formation.


Amniotic Fluid Cytosol Fraction Kidney Cortex Acid Labile Molecular Weight Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Boyd GW (1972) The nature of renal renin. In: Genest J, Koiw E (eds) Hypertension 72. Springer, Berlin/Heidelberg/New York, pp 161–169Google Scholar
  2. 2.
    Day RP, Luetscher JA, Gonzales CM (1975) Occurrence of big renin in human plasma, amniotic fluid and kidney extracts. J Clin Endocrinol Metab 40: 1078–1084PubMedCrossRefGoogle Scholar
  3. 3.
    Day RP, Luetscher JA (1974) Big renin: A possible prohormone in kidney and plasma of a patient with Wilms’ tumor. J Clin Endocrinol Metab 38: 923–926PubMedCrossRefGoogle Scholar
  4. 4.
    Funakawa S, Funae Y, Yamamoto K (1978) Conversion between renin and high-molecular-weight renin in the dog. Biochem J 176: 977–981PubMedGoogle Scholar
  5. 5.
    Kawamura M, Ikemoto F, Yamamoto K (1979) Characteristics of a renin-binding substance for the conversion of renin into a higher-molecular-weight form in the dog. Clin Sci 57: 345–350PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1981

Authors and Affiliations

  • Kenjiro Yamamoto
  • Fumihiko Ikemoto
  • Kazuo Takaori
  • Minoru Kawamura

There are no affiliations available

Personalised recommendations