Interpretation of the Hypertension Detection and Follow-up Program

  • Richard D. Remington

Abstract

Five months ago, the Hypertension Detection and Follow-up Program (HDFP) reported findings for its primary design end point, all cause mortality (1, 2). This community-based randomized trial screened 158,906 individuals aged 30–69 in 14 communities nationwide. Attempts were made to enroll all individuals with blood pressure elevations maintained through two screenings, at home and in the clinic, and high participation rates were achieved. Because very few individuals were to be excluded, it was ethically unfeasible to use placebos, thereby blocking treatment for persons with very high blood pressures. Participants were randomly assigned to stepped care or referred care groups, and the randomization was effective in equating the groups. Referred care participants received a full base-line examination and were then sent to their usual source of care in the community, while participating in annual follow-up examinations under study auspices.

Keywords

Placebo Toxicity Chlorthalidone 

References

  1. 1.
    Hypertension Detection and Follow-up Program Cooperative Group (1979) Five-year findings of the Hypertension Detection and Follow-up Program: I. Reduction in mortality of persons with high blood pressure, including mild hypertension. JAMA 242: 2562–2571CrossRefGoogle Scholar
  2. 2.
    Hypertension Detection and Follow-up Program Cooperative Group (1979) Five-year findings of the Hypertension Detection and Follow-up Program: II. Mortality by race-sex and age. JAMA 242: 2572–2577CrossRefGoogle Scholar
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    Hypertension Detection and Follow-up Program Cooperative Group (1977) Blood pressure studies in 14 communities: A two-stage screen for hypertension. JAMA 237: 2385–2391CrossRefGoogle Scholar
  4. 4.
    Hypertension Detection and Follow-up Program Cooperative Group (1977) The Hypertension Detection and Follow-up Program: A progress report. Circ Res 40 (Suppl 1): 106–109Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1981

Authors and Affiliations

  • Richard D. Remington

There are no affiliations available

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