Position Paper: The Concept of Whole Body Autoregulation and the Dominant Role of the Kidneys for Long-term Blood Pressure Regulation

  • Arthur C. Guyton
  • John E. Hall
  • Thomas E. Lohmeier
  • R. Davis ManningJr.
  • Thomas E. Jackson
Conference paper

Abstract

This paper addresses two different topics: a) the concept of whole body autoregulation; and b) the role of the kidneys for long-term blood pressure regulation. In the minds of most persons in the field of hypertension research, these are interdependent phenomena. However, this is quite untrue. One of the purposes of this paper will be to point out the independence of these two phenomena, to show that each one of them can function independently of the other—though, at times, they do function together.

Keywords

Dioxide Hydration Filtration Creatinine Angiotensin 

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References

  1. 1.
    Guyton AC, Ross JM, Carrier O Jr, Walker JR (1964) Evidence for tissue oxygen demand as the major factor causing autoregulation. Circ Res 14 (1): 60–69Google Scholar
  2. 2.
    Guyton AC (1980) Arterial pressure and hypertension. Saunders, Philadelphia, PaGoogle Scholar
  3. 3.
    Granger H J, Guyton AC (1969) Autoregulation of the total systemic circulation following destruction of the central nervous system in the dog. Circ Res 25: 379–388PubMedGoogle Scholar
  4. 4.
    Smithwick RH (1951) Hypertensive cardiovascular disease: The effect of thoracolumbar splanchnicetomy upon mortality and survival rates. JAMA 147: 1611–1615Google Scholar
  5. 5.
    Kolsters G, Schalekamp MADH, Birkenhager WH, Lever AF (1975) Renin and renal function in benign essential hypertension: Evidence for a renal abnormality. In: Berglund G, Hansson L, Werko L, Lindgren A, Soner AB (eds) Pathophysiology and management of arterial hypertension, Molndal, Sweden, p 54Google Scholar
  6. 6.
    Houck CR (1954) Effect of hydration and dehydration and hypertension in chronic bilaterally nephrectomized dog. J Physiol 176: 183–189PubMedGoogle Scholar
  7. 7.
    Borst JGG, Borst-DeGeus A (1963) Hypertension explained by Starling’s theory of circulatory homeostasis. Lancet 1: 677–682PubMedCrossRefGoogle Scholar
  8. 8.
    Ledingham JM, Cohen RD (1964) Changes in the extracellular fluid volume and cardiac output during the development of experimental renal hypertension. Can Med Assoc J 90: 292–294PubMedGoogle Scholar
  9. 9.
    Langston JB, Guyton AC, Douglas BH, Dorsett PE (1963) Effect of changes in salt intake on arterial pressure and renal function in nephrectomized dogs. Circ Res 12: 508–513Google Scholar
  10. 10.
    Douglas BH, Guyton AC, Langston JB, Bishop VS (1964) Hypertension caused by salt loading: II. Fluid volume and tissue pressure changes. Am J Physiol 207: 669–671PubMedGoogle Scholar
  11. 11.
    Coleman TG, Guyton AC (1969) Hypertension caused by salt loading in the dog: III. Onset transients of cardiac output and other circulatory variables. Circ Res 25: 152–160Google Scholar
  12. 12.
    Cowley AW Jr, Guyton AC (1974) Baroreceptor reflex contribution in angiotensin II induced hypertension. Circulation 50 (3): 60Google Scholar
  13. 13.
    Manning RD Jr, Coleman TG, Guyton AC, Norman RA Jr, McCaa RE (1979) Essential role of mean circulatory filling pressure in salt-induced hypertension. Am J Physiol 236: R40–R47PubMedGoogle Scholar
  14. 14.
    Guyton AC, Coleman TG (1967) Long-term regulation of the circulation: Interrelationships with body fluid volumes. In: Reeve EB, Guyton AC (eds) Physical bases of circulatory transport-regulation and exchange. Saunders, Philadelphia, Pa, pp 179–201Google Scholar
  15. 15.
    Guyton AC, Coleman TG, Cowley AW Jr, Manning RD Jr, Norman RA Jr, Ferguson JD (1974) A systems analysis approach to understanding long- range arterial blood pressure control and hypertension. Circ Res 35: 159–176Google Scholar
  16. 16.
    Dahl LK, Heine M (1975) Primary role of renal homografts in setting blood pressure levels in rats. Circ Res 36: 692–696PubMedGoogle Scholar
  17. 17.
    Bianchi G, Fox U, KiFrancesco GF, Giovanetti AM, Pagetti D (1974) Blood pressure changes produced by kidney cross-transplantation between spontaneously hypertensive rats (SHR) and normotensive rats (NR). Clin Sci Mol Med 47: 435–448PubMedGoogle Scholar
  18. 18.
    Kawabe K, Watanabe TX, Shiono K, Sokabe H (1978) Influence on blood pressure of renal isografts between spontaneously hypertensive and normoten- sive rats, utilizing the Fi hybrids. Jpn Heart J 19: 886–894PubMedCrossRefGoogle Scholar
  19. 19.
    Selkurt EE, Hall PW, Spencer MP (1949) Influence of graded arterial pressure decrement on renal clearance of creatinine, σ-amino hippurate and sodium. Am J Physiol 159: 369–378PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1981

Authors and Affiliations

  • Arthur C. Guyton
  • John E. Hall
  • Thomas E. Lohmeier
  • R. Davis ManningJr.
  • Thomas E. Jackson

There are no affiliations available

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