Abstract
A new method capable of determining net Na+ and K+ fluxes across red blood cell membranes has been described in our laboratory. This method has enabled us to demonstrate, in Na+-loaded/K+- depleted erythrocytes, the existence of major abnormalities characteristic of essential (primary) hypertension (1, 2).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Garay RP, Meyer P (1979) A new test showing abnormal net Na+ and K+ fluxes in erythrocytes of essential hypertensive patients. Lancet 1: 349- 353
Garay RP, Elghozi JL, Dagher G, Meyer P (1980) Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes. New Engl J Med 302: 769
Garay RP, Elghozi JL, Dagher G, Meyer P (1980) Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes. New Engl J Med 302: 769
Garay RP, Dagher G, Pernollet MG, Devynck MA, Meyer P (1980) Inherited defect in a Na+,K+-co- transport system in erythrocytes from essential hypertensive patients. Nature 284: 281
Canessa M, Adragna N, Solomon H, Connolly T, Tosteson D (1980) Increased sodium-lithium coun- tertransport in red cells of patients with essential hypertension. New Engl J Med 302: 772
Postnov YV, Orlov SN, Shevchenko AS, Adler AM (1977) Altered sodium permeability, calcium binding and Na,K-ATPase activity in red blood cell membranes in essential hypertension. Pfluegers Arch 371: 263
De Mendonca M, Grichois ML, Garay RP, Sassard J, Ben-Ishay D, Meyer, P (in press) Abnormal net Na+ and K+ fluxes in erythrocytes of three varieties of genetically hypertensive rats. Proc Natl Acad Sci USA
Blaustein MP (1977) Sodium ions, calcium ions, blood pressure regulation and hypertension: A reassessment and a hypothesis. Am J Physiol 232 (2): C165
Edmondson RPS, Thomas RD, Hilton PJ, Jones NH (1975) Abnormal leukocyte composition and Na transport in essential hypertension. Lancet 1: 1003
Mattiasson I, Mattiasson B, Hood B (1979) The efflux rate of norepinephrine from platelets and its relation to blood pressure. Life Sci 2: 2265
Kwan CY, Belbeck L, Daniel EE (1980) Abnormal biochemistry of vascular smooth muscle plasma membrane isolated from hypertensive rats. Mol Pharmacol 17: 137
Postnov YV, Orlov S, Pokudin NI (1979) Decrease of calcium binding in the red blood cell membranes in spontaneously hypertensive rats and in essential hypertension. Pfluegers Arch 379: 191
Postnov YV, Orlov SN (1979) Features of intracellular calcium distribution in the adipose tissue of spontaneously hypertensive rats ( SHR ). Experientia 35: 1480
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer-Verlag New York Inc.
About this paper
Cite this paper
Garay, R.P., Meyer, P. (1981). Erythrocyte Sodium Extrusion in Primary Hypertension. In: Laragh, J.H., Bühler, F.R., Seldin, D.W. (eds) Frontiers in Hypertension Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5899-5_16
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5899-5_16
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-5901-5
Online ISBN: 978-1-4612-5899-5
eBook Packages: Springer Book Archive