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Erythrocyte Sodium Extrusion in Primary Hypertension

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Frontiers in Hypertension Research
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Abstract

A new method capable of determining net Na+ and K+ fluxes across red blood cell membranes has been described in our laboratory. This method has enabled us to demonstrate, in Na+-loaded/K+- depleted erythrocytes, the existence of major abnormalities characteristic of essential (primary) hypertension (1, 2).

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References

  1. Garay RP, Meyer P (1979) A new test showing abnormal net Na+ and K+ fluxes in erythrocytes of essential hypertensive patients. Lancet 1: 349- 353

    Article  PubMed  CAS  Google Scholar 

  2. Garay RP, Elghozi JL, Dagher G, Meyer P (1980) Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes. New Engl J Med 302: 769

    Article  PubMed  CAS  Google Scholar 

  3. Garay RP, Elghozi JL, Dagher G, Meyer P (1980) Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes. New Engl J Med 302: 769

    Article  PubMed  CAS  Google Scholar 

  4. Garay RP, Dagher G, Pernollet MG, Devynck MA, Meyer P (1980) Inherited defect in a Na+,K+-co- transport system in erythrocytes from essential hypertensive patients. Nature 284: 281

    Article  PubMed  CAS  Google Scholar 

  5. Canessa M, Adragna N, Solomon H, Connolly T, Tosteson D (1980) Increased sodium-lithium coun- tertransport in red cells of patients with essential hypertension. New Engl J Med 302: 772

    Article  PubMed  CAS  Google Scholar 

  6. Postnov YV, Orlov SN, Shevchenko AS, Adler AM (1977) Altered sodium permeability, calcium binding and Na,K-ATPase activity in red blood cell membranes in essential hypertension. Pfluegers Arch 371: 263

    Article  CAS  Google Scholar 

  7. De Mendonca M, Grichois ML, Garay RP, Sassard J, Ben-Ishay D, Meyer, P (in press) Abnormal net Na+ and K+ fluxes in erythrocytes of three varieties of genetically hypertensive rats. Proc Natl Acad Sci USA

    Google Scholar 

  8. Blaustein MP (1977) Sodium ions, calcium ions, blood pressure regulation and hypertension: A reassessment and a hypothesis. Am J Physiol 232 (2): C165

    PubMed  CAS  Google Scholar 

  9. Edmondson RPS, Thomas RD, Hilton PJ, Jones NH (1975) Abnormal leukocyte composition and Na transport in essential hypertension. Lancet 1: 1003

    Article  PubMed  CAS  Google Scholar 

  10. Mattiasson I, Mattiasson B, Hood B (1979) The efflux rate of norepinephrine from platelets and its relation to blood pressure. Life Sci 2: 2265

    Article  Google Scholar 

  11. Kwan CY, Belbeck L, Daniel EE (1980) Abnormal biochemistry of vascular smooth muscle plasma membrane isolated from hypertensive rats. Mol Pharmacol 17: 137

    PubMed  CAS  Google Scholar 

  12. Postnov YV, Orlov S, Pokudin NI (1979) Decrease of calcium binding in the red blood cell membranes in spontaneously hypertensive rats and in essential hypertension. Pfluegers Arch 379: 191

    Article  CAS  Google Scholar 

  13. Postnov YV, Orlov SN (1979) Features of intracellular calcium distribution in the adipose tissue of spontaneously hypertensive rats ( SHR ). Experientia 35: 1480

    Google Scholar 

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© 1981 Springer-Verlag New York Inc.

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Garay, R.P., Meyer, P. (1981). Erythrocyte Sodium Extrusion in Primary Hypertension. In: Laragh, J.H., Bühler, F.R., Seldin, D.W. (eds) Frontiers in Hypertension Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5899-5_16

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  • DOI: https://doi.org/10.1007/978-1-4612-5899-5_16

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5901-5

  • Online ISBN: 978-1-4612-5899-5

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