Advertisement

Sodium and Other Dietary Factors in Experimental and Human Hypertension: The Japanese Experience

  • Yukio Yamori
  • Yasuo Nara
  • Masahiro Kihara
  • Ryoichi Horie
  • Akira Ooshima

Abstract

Stroke is the most preponderant cause of death in Japan, while myocardial infarction is the first cause of death in Western countries. Epidemiologic studies have indicated that stroke incidence in Japan, which is closely related to hypertension itself, is rather inversely correlated with serum cholesterol levels that are generally far lower than those of the populations in Western countries; the mean of the various populations in Japan is mostly below 200 mg/dl. Since the stroke incidence is higher in rural inhabitants in Japan who are taking less cholesterol and protein, but excess salt (the mean daily intake is mostly over 12 g, not infrequently over 20 g), salt excess seems to be more closely related to high stroke incidence.

Keywords

Protein Intake Stroke Incidence Salt Sensitivity Rural Inhabitant Human Hypertension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Yamori Y, Nagaoka A, Okamoto K (1974) Importance of genetic factors in hypertensive cerebrovascular lesions: An evidence obtained by successive selective breeding of stroke-prone and resistant SHR. Jpn Circ J 38: 1095–1110Google Scholar
  2. 2.
    Okamoto K, Yamori Y, Nagaoka A (1974) Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res 34, (Suppl 1): 143–153Google Scholar
  3. 3.
    Yamori Y, Lovenberg W, Freis E (eds) (1979) Prophylactic approach to hypertensive diseases. Raven Press, New YorkGoogle Scholar
  4. 4.
    Yamori Y (1977) Hypertensive strains of rat. In: Inoue E, Nishimura H (eds) Gene-environment interaction in common diseases. University of Tokyo Press, Tokyo, pp 151–154Google Scholar
  5. 5.
    Yamori Y, Horie R, Ohtaka M, Nara Y, Ooshima A (1979) Electrolyte balance in stroke-prone and -resistant SHR. Jpn Heart J 20 (Suppl 1): 65–67Google Scholar
  6. 6.
    Yamori Y, Horie R, Akiguchi I, Ohtaka M, Nara Y, Fukase M (1976) New models of SHR for studies on stroke and atherogenesis. Clin Exp Pharmacol Physiol [Suppl] 3: 199–203CrossRefGoogle Scholar
  7. 7.
    Yamori Y, Horie R, Handa H, Nara Y, Ohtaka M, Fukase M (1977) Cerebral circulation and elec-troencephalographical approach to stroke in stroke- prone SHR. In: Spontaneous hypertension. DHEW Publication No. (NIH) 77-1179, pp 279–286Google Scholar
  8. 8.
    Yamori Y, Horie R, Akiguchi I, Nara Y, Ohtaka M, Fukase M (1977) Pathogenetic mechanism of stroke in stroke-prone SHR. In: de Jong W (ed) Progress in brain research, Vol 47: Hypertension and brain mechanisms. Elsevier, Amsterdam, pp 219–234Google Scholar
  9. 9.
    Yamori Y, Horie R, Nara Y, Ikeda K (1977) Pro-phylactic trials for stroke in stroke-prone SHR: I. Effects of fat, protein and amino acids. Jpn Heart J 18: 551–553Google Scholar
  10. 10.
    Yamori Y, Horie R, Ohtaka M, Nara Y, Fukase M (1976) Effect of hypercholesterolemic diet on the incidence of cerebrovascular and myocardial lesions in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol [Suppl] 3: 205–208Google Scholar
  11. 11.
    Yamori Y, Horie R (1977) Vascular reactivity in pathological states. In: Shibata S, Canier O (eds) Factors influencing vascular reactivity. Igaku- Shoin, TokyoGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1981

Authors and Affiliations

  • Yukio Yamori
  • Yasuo Nara
  • Masahiro Kihara
  • Ryoichi Horie
  • Akira Ooshima

There are no affiliations available

Personalised recommendations