Abstract
Cytochrome oxidase is specifically served by oxygen delivery from the blood, and affords the main energy conservation pathway of the eukaryotic cell. The mechanism by which cytochrome oxidase reduces to water the total oxygen delivery and affords efficient production of ATP without production of toxic intermediates of oxygen reduction is one of the principal problems of modern biochemistry, on which significant advances have been made recently. The quantitation of structural and functional features of cytochrome oxidase has been obtained by low dose electron microscopy, low angle diffraction from oriented bilayers, and most recently anomalous scattering. These approaches are complemented by low temperature kinetics and sensitive spectrophotometry to afford a “first step” toward the correlation of structural and functional aspects of cytochrome oxidase and the cytochrome oxidase-oxygen reaction mechanism.
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References
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Chance, B. (1981). The Reaction of Oxygen with Cytochrome Oxidase: The Role of Sequestered Intermediates. In: Gilbert, D.L. (eds) Oxygen and Living Processes. Topics in Environmental Physiology and Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5890-2_10
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DOI: https://doi.org/10.1007/978-1-4612-5890-2_10
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