Clinical Trials of Topical Antimicrobials

  • Alfred M. Allen


Clinical trials of topical antimicrobials have improved substantially over the past 20 years. Two decades ago, trials of these agents typically lacked “double blindness” and randomized allocation of medication. Many did not even have controls; comparisons were based on investigators’ impressions of what would have happened in the absence of treatment.


True Difference Tinea Pedis Equivalent Efficacy Good Patient Result Tinea Cruris 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Allen AM (1978) Clinical trials in dermatology: Part 1, Experimental design. Int J Dermatol 17:42–51PubMedCrossRefGoogle Scholar
  2. 2.
    Allen AM (1978) Clinical trials in dermatology: Part 2, Numbers of patients required. Int J Dermatol 17:194–203PubMedCrossRefGoogle Scholar
  3. 3.
    Allen AM Clinical trials in dermatology: Part 4, Analysis and interpretation. Int J Dermatol (to be published)Google Scholar
  4. 4.
    Dillon HC (1970) The treatment of pyoderma in children. J Pediat 76:676–684PubMedCrossRefGoogle Scholar
  5. 5.
    Esterley NB, Markowitz M The treatment of pyoderma in children. JAMA 212:1667–1670Google Scholar
  6. 6.
    Fleiss JC (1973) Statistical methods for rates and proporitons. John Wiley & Sons, New York 176–194Google Scholar
  7. 7.
    Hughes WT, Wan RT (1967) Impetigo contagiosa: etiology, complications, and comparison of therapeutic effectiveness of erythromycin and antibiotic ointment. Am J Dis Child 113:449–453PubMedGoogle Scholar
  8. 8.
    Kuflik EG, Howie CR, Nelson PI (1971) An evaluation of topical antifungal therapy in servicemen. Cutis 7:287–290Google Scholar
  9. 9.
    Lubowe II, Wexler L (1965) Comparative study of tolnaftate solution and compound undecylenic acid ointment N.F. in the treatment of epidermophytoses. Curr Ther Res 7:401–405PubMedGoogle Scholar
  10. 10.
    Mainland D (1963) Elementary Medical Statistics. 2nd ed. WB Saunders Co., Philadelphia, pp 368–370Google Scholar
  11. 11.
    Rennie D (1978) Editorial: Vive La Difference (P < 0.05). N Engl J Med 299:828–829PubMedCrossRefGoogle Scholar
  12. 12.
    Roberts SOB Champion RH (1968) Treatment of ringworm infections with tolnaftate ointment. Practitioner 199:797–798Google Scholar
  13. 13.
    Tschen EH, Becker LE, Ulrich JA, Hoge WH, Smith EB (1979) Comparison of over-the-counter agents for tinea pedis. Cutis 23:696–698PubMedGoogle Scholar
  14. 14.
    Zaynoun ST, Matla MT, Uwayda MM. Cutis 23:696–698PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1981

Authors and Affiliations

  • Alfred M. Allen

There are no affiliations available

Personalised recommendations