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Short-Term Tests for Chemical Carcinogens pp 483–504Cite as

Mutagenicity Testing: Problems in Application

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Part of the book series: Topics in Environmental Physiology and Medicine ((TEPHY))

Abstract

In this decade, genetic toxicology has emerged as an interdisciplinary science that aims to understand the mechanisms of action of agents that induce mutations and to appraise the human risks posed by exposure to such agents. Our research into chemical mutagenesis has shown us that some chemical types in themselves or after metabolic activation are capable of altering the informational content encoded in the base sequence of DNA. It now becomes understandable that adverse health effects in man such as carcinogenesis, mutagenesis, and teratogenesis may result from overexposure to such chemicals that alter genetic material. Thus it behooves us as scientists to use the many mutagenicity testing methods that have been developed—and are being developed—to study these genotoxic substances.

This manuscript has been supported by EPA Grant R804621020 (Project Officer: Dr. J.F. Stara).

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Authors
  1. Marvin S. Legator
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  2. Stephen J. Rinkus
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Editor information

Editors and Affiliations

  1. Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    H. F. Stich (Head) (Head)

  2. Carcinogen Testing Laboratory, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    R. H. C. San (Chief) (Chief)

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© 1981 Springer-Verlag New York Inc.

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Legator, M.S., Rinkus, S.J. (1981). Mutagenicity Testing: Problems in Application. In: Stich, H.F., San, R.H.C. (eds) Short-Term Tests for Chemical Carcinogens. Topics in Environmental Physiology and Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5847-6_43

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  • DOI: https://doi.org/10.1007/978-1-4612-5847-6_43

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5849-0

  • Online ISBN: 978-1-4612-5847-6

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