Induction of a Resistant Preneoplastic Liver Cell as a New Principle for a Short-Term Assay in vivo for Carcinogens
The past few years have seen the development of a large number (over 60) of new tests designed to detect and identify possible carcinogens in man’s environment. The test organisms and the endpoints used vary widely in detail but in general the assays fall into two groups. The tests in the smallest group use a complex cellular response, cell transformation, as the indicator. This response resembles in several respects malignant neoplasia and is considered to be a valid in vitro analogue of cancer induction in vivo. The tests in the largest group use some aspect of DNA damage and/or repair or some presumed reflection of damage or repair of DNA, such as mutations, chromosome damage, chromatid exchanges, etc. The chemical-biochemical basis of the transformation tests is unknown.
KeywordsPartial Hepatectomy Cancer Induction Liver Carcinogenesis Ethyl Carbamate Genotoxic Assay
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- Foulds, L. (1975): Neoplastic Development, Vol. 2. London: Academic Press.Google Scholar
- Ogawa, H., Medline, A., Farber, E. (1979): Sequential analysis of hepatic carcinogenesis: A comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal and regenerating liver. Lab. Invest. 40: 22–35.Google Scholar
- Solt, D., Farber, E. (1977): Persistence of carcinogen-induced initiated hepatocytes in liver carcinogenesis. Proc. Am Assoc. Cancer Res. 18: 52.Google Scholar
- Tsuda, H., Farber, E. (1979): Initiation of putative preneoplastic liver lesions by single doses of non-liver and liver carcinogens plus partial hepatectomy (PH). Proc. Am. Assoc. Cancer Res. 20: 15.Google Scholar
- Ying, T.S., Sarma, D.S.R. (1979): Role of cell necrosis in the induction of preneoplastic lesions. Proc. Am. Assoc. Cancer Res. 20: 14.Google Scholar