Liver Culture Indicators for the Detection of Chemical Carcinogens

  • Gary M. Williams
Conference paper
Part of the Topics in Environmental Physiology and Medicine book series (TEPHY)

Abstract

In any test system under consideration for inclusion in a battery of short-term tests for carcinogens, the two principal components that determine the usefulness of the test are the metabolizing system and the endpoint of the test (Williams, 1980a). Tests involving intact mammalian cells offer potential advantages in both components, by providing intracellular metabolism of chemicals within the target cell and reliable endpoints whose biological significance is clear. The development of liver-derived test systems has been pursued because liver possesses the broadest capability of any organ for metabolizing chemical carcinogens (Weisburger and Williams, 1975). We have suggested that the most useful endpoints in mammalian cells to supplement bacterial mutagenesis tests in a battery would be DNA repair, sister chromatid exchange, mutagenesis, and transformation (Weisburger and Williams, 1978; 1980b).

Keywords

Chemical Carcinogen Mutagenesis Assay Repair Test Methylazoxymethanol Acetate Culture Liver Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1981

Authors and Affiliations

  • Gary M. Williams

There are no affiliations available

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