Benign Tumors

  • William P. LongmireJr.
  • Ronald K. Tompkins
Part of the Comprehensive Manuals of Surgical Specialties book series (CMSS)


Benign lesions of the liver are relatively, rare compared to primary and metastatic hepatic tumors. They present a challenge not only in their initial diagnosis, but also in the selection of proper treatment. Since they usually are slow growing and, in several instances, actually congenital, routine liver function tests seldom suggest the need for further investigation. Only when they reach sufficient size to be palpated or to obstruct the biliary ducts or adjacent organs are they discovered preoperatively (Fig. 6.1). The symptoms produced by these larger benign tumors may be related to stretching of Glisson’s capsule or pressure on adjacent viscera or the parietal peritoneum. For example, recently a tumor was found when obstruction of the gastric outlet produced vomiting. More frequently the presenting complaint is obstruction of the biliary tree by these tumors. Symptoms often mimic acute or chronic cholecystitis. An additional presentation, not at all uncommon, is the sudden onset of pain and rapid increase in size associated with hemorrhage into, or from, pre-existing tumors. Thrombosis and infarction of vascular tumors, such as hemangiomas, also produce rapid onset of symptoms.


Bile Duct Oral Contraceptive Benign Tumor Focal Nodular Hyperplasia Cavernous Hemangioma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Baum JK, Holtz F, Bookstein JJ, Klein EW: Possible association between benign hepatomas and oral contraceptives. Lancet 2: 926–929, 1973PubMedCrossRefGoogle Scholar
  2. 2.
    Braun P, Ducharme JC, Riopelle JL, Davignon, A: Hemangiomatosis of the liver in infants. J Pediatr Surg 10: 121–126, 1975PubMedCrossRefGoogle Scholar
  3. 3.
    Burdette WJ: Neoplasms of the liver. In L Schiff (ed), Diseases of the Liver, 4th ed. Philadelphia, Lippincott, 1975, pp 1051–1077Google Scholar
  4. 4.
    Chowdhury AR, Black M, Lorber SH, Chey WY: Hemangioendotheliomatosis of the liver. A 12-year follow-up. Gastroenterology 72: 157–160, 1977PubMedGoogle Scholar
  5. 5.
    Christopherson WW, Mays ET, Barrows GH: Liver oncogenesis and steroid. In IM Ariel (ed), Progress in Clinical Cancer, Vol. 7. New York, Grune & Stratton, 1978, pp 153–163Google Scholar
  6. 6.
    Davis JB, Schenken JR, Zimmerman O: Massive hemoperitoneum from rupture of benign hepatocellular adenoma. Surgery 73: 181–184, 1973PubMedGoogle Scholar
  7. 7.
    Edmondson HA: Tumors of the Liver and Intrahepatic Bile Ducts. Atlas of Tumor Pathology, Section 7, Fascicle 25. Washington DC, Armed Forces Institute of Pathology, 1958Google Scholar
  8. 8.
    Edmondson HA, Henderson B, Benton B: Liver cell adenomas associated with use of oral contraceptives. N Engl J Med 294: 470–472, 1976PubMedCrossRefGoogle Scholar
  9. 9.
    Foster JH, Berman MM: Solid Liver Tumors. Major Problems in Clinical Surgery, Vol. 22. Philadelphia, Saunders, 1977, pp 29–56Google Scholar
  10. 10.
    Grabowski M, Stenram U, Bergqvist A: Focal nodular hyperplasia of the liver, benign hepatomas, oral contraceptives and other drugs affecting the liver. Acta Pathol Microbiol Scand [A] 83: 615–622, 1975Google Scholar
  11. 11.
    Horvath E, Kovacs K, Ross RC: Ultrastructural findings in a well-differentiated hepatoma. Digestion 7: 74–82, 1972PubMedCrossRefGoogle Scholar
  12. 12.
    Ishak KG, Rabin L: Benign tumors of the liver. Med Clin North Am 59: 995–1013, 1975PubMedGoogle Scholar
  13. 13.
    McAvoy JM, Tompkins RK, Longmire WP Jr: Benign hepatic tumors and their association with oral contraceptives. Arch Surg 111: 761–767, 1976PubMedGoogle Scholar
  14. 14.
    Starzl T: Surgical treatment of hepatic adenoma and focal nodular hyperplasia. Gastroenterology 75: 518–521, 1978PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1981

Authors and Affiliations

  • William P. LongmireJr.
    • 1
  • Ronald K. Tompkins
    • 2
  1. 1.Department of SurgeryUCLA School of MedicineLos AngelesUSA
  2. 2.UCLA School of MedicineLos AngelesUSA

Personalised recommendations