Modulation of Lymphocyte Function by Copper and Thiols

  • Peter E. Lipsky
Part of the Experimental Biology and Medicine book series (EBAM, volume 2)


Clinical trials have established that a number of drugs are effective in the treatment of rheumatoid arthritis despite having only minimal non-specific anti-inflammatory properties. This group of agents includes D-penicillamine, a mercapto amino acid that has clearly been shown to have the capacity to suppress rheumatoid inflammation (1). More recent evidence indicates that other mercaptans, such as 5-thiopyridoxine (2) and 2-mercaptopropionylglycine (3,4) may be as effective as D-penicillamine in the treatment of rheumatoid arthritis. Despite the clinical evidence of their efficacy, the mechanism of action of these agents in rheumatoid arthritis remains unclear.


Rheumatoid Arthritis Lymphocyte Function Peripheral Blood Mononuclear Total Lymphoid Irradiation Rheumatoid Factor Titer 
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Copyright information

© The Humana Press Inc. 1982

Authors and Affiliations

  • Peter E. Lipsky
    • 1
  1. 1.Department of Internal MedicineUTHSCD Southwestern Medical SchoolDallasUSA

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