Advertisement

Modulation of Lymphocyte Function by Copper and Thiols

  • Peter E. Lipsky
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 2)

Abstract

Clinical trials have established that a number of drugs are effective in the treatment of rheumatoid arthritis despite having only minimal non-specific anti-inflammatory properties. This group of agents includes D-penicillamine, a mercapto amino acid that has clearly been shown to have the capacity to suppress rheumatoid inflammation (1). More recent evidence indicates that other mercaptans, such as 5-thiopyridoxine (2) and 2-mercaptopropionylglycine (3,4) may be as effective as D-penicillamine in the treatment of rheumatoid arthritis. Despite the clinical evidence of their efficacy, the mechanism of action of these agents in rheumatoid arthritis remains unclear.

Keywords

Rheumatoid Arthritis Lymphocyte Function Peripheral Blood Mononuclear Total Lymphoid Irradiation Rheumatoid Factor Titer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Multicentre Trial Group, Lancet, I, 275 (1973).Google Scholar
  2. 2.
    E. C. Huskisson, I. A. Jaffe, J. Scott, and P. A. Dieppe, Arthritis Rheum., 23, 106 (1980).PubMedCrossRefGoogle Scholar
  3. 3.
    B. Amor, C. Mery, and A. Degery, Revue Rheum., 47, 157 (1980).Google Scholar
  4. 4.
    G. Pasero, P. Pellegrini, M. L. Ciompi, V. Colamussi, P. Barbieri, and M. R. Mazzoni, Revue Rheum., 47, 163 (1980).Google Scholar
  5. 5.
    N. J. Zvaifler, Adv. Immunol., 16, 265 (1973).PubMedCrossRefGoogle Scholar
  6. 6.
    H. E. Paulus, H. I. Machleder, S. Levine, D. T. Y. Yu, and N. S. MacDonald, Arthritis Rheum., 20, 1249 (1977).PubMedCrossRefGoogle Scholar
  7. 7.
    Cooperating Clinics of the American Rheumatism Association, New Engl. J. Med., 283, 883 (1970).CrossRefGoogle Scholar
  8. 8.
    M. B. Urowitz, D. A. Gordon, H. A. Smythe, W. Pruszanski, and M. A. Ogryzlo, Arthritis Rheum., 16, 411 (1973).PubMedCrossRefGoogle Scholar
  9. 9.
    D. J. Wallace, D. Goldfinger, R. Gatti, Lowe, P. Fan, R. Bluestone, and J. R. Klinenberg, Arthritis Rheum., 22, 703 (1979).PubMedCrossRefGoogle Scholar
  10. 10.
    D. G. Wright, J. Karsh, A. S. Fauci, J. H. Klippel, A. B. Deisseroth, and J. L. Decker, Clin. Res., 27, 339A (1979).Google Scholar
  11. 11.
    B. L. Kotzin, S. Strober, S. Slavin, M. Gottlieb, A. Calin, J. Fries, R. Hoppe, and H. S. Kaplan, Arthritis Rheum., 22, 632 (1979).Google Scholar
  12. 12.
    B. L. Kotzin, S. Strober, A. Calin, E. Engleman, R. Hoppe, and H. S. Kaplan, Clin. Res., 29, 558A (1981).Google Scholar
  13. 13.
    D. Trentham, J. Belli, J. Buckley, E.HToetzl, R. Anderson, J. David, S. Hellman, and K. F. Austen, Clin. Res., 29, 585A (1981).Google Scholar
  14. 14.
    I. A. Jaffe, Ann. Rheum. Dis., 22, 71 (1963).PubMedCrossRefGoogle Scholar
  15. 15.
    I. A. Jaffe, Arthritis Rheum., 8, 1064 (1965).PubMedCrossRefGoogle Scholar
  16. 16.
    J. R. Zuckner, R. H. Ramsey, R. W. Dorner, and G. E. Gantner, Jr., Arthritis Rheum., U9 131 (1970).Google Scholar
  17. 17.
    I. A. Jaffe, Ann. N.Y. Acad. Sci., 256, 330 (1975).PubMedCrossRefGoogle Scholar
  18. 18.
    I. Mohammed, D. Barraclough, E. J. Holborow, and B. M. Ansell, Ann. Rheum. Dis., 35, 458 (1976).CrossRefGoogle Scholar
  19. 19.
    O. Epstein, D. Devilliers, S. Jain, B. J. Potter, H. C. Thomas, and S. Sherlock, New Engl. J. Med., 300, 274 (1979).PubMedCrossRefGoogle Scholar
  20. 20.
    R. Bluestone, and L. S. Goldberg, Ann. Rheum. Dis., 32, 50 (1973).PubMedCrossRefGoogle Scholar
  21. 21.
    I. M. Hunneyball, G. A. Stewart, and D. R. Stanworth, Immunology, 34, 1053 (1978).PubMedGoogle Scholar
  22. 22.
    I. M. Hunneyball, G. A. Stewart, and D. R. Stanworth, Immunology, 35, 159 (1978).PubMedGoogle Scholar
  23. 23.
    P. E. Lipsky, and M. Ziff, J. Immunol., 120, 1006 (1978).PubMedGoogle Scholar
  24. 24.
    P. E. Lipsky, and M. Ziff, J. Clin. Invest., 65, 1069 (1980).PubMedCrossRefGoogle Scholar
  25. 25.
    P. E. Lipsky, and M. Ziff, J. Clin. Invest., 59, 455 (1977).PubMedCrossRefGoogle Scholar
  26. 26.
    S. A. Rosenberg, and P. E. Lipsky, J. Immunol., 122, 926 (1979).PubMedGoogle Scholar
  27. 27.
    J. A. Van Boxel, and S. A. Paget, New Engl. J. Med., 293, 517 (1975).PubMedCrossRefGoogle Scholar
  28. 28.
    D. T. Y. Yu, R. J. Winchester, S. M. Fu, A. Gibofsky, H. S. Ko, and H. G. Kunkel, J. Exp. Med., 151, 91 (1980).PubMedCrossRefGoogle Scholar
  29. 29.
    G. R. Burmester, D. T. Y. Yu, A.-M. Irani, TTG. Kunkel, and R. J. Winchester, Clin. Res., 29, 483A (1981).Google Scholar
  30. 30.
    P. Stastny, M. Rosenthal, M. Andreis, and M. Ziff, Arthritis Rheum., 18, 237 (1975).PubMedCrossRefGoogle Scholar
  31. 31.
    M.W. Whitehouse, L. Field, C.W. Denko, and R. Ryall, Scand. J. Rheum., 4 (Suppl. 8), 183 (1975).Google Scholar
  32. 32.
    J. R. J. Sorenson, J. Med. Chem., 19, 135 (1976).PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1982

Authors and Affiliations

  • Peter E. Lipsky
    • 1
  1. 1.Department of Internal MedicineUTHSCD Southwestern Medical SchoolDallasUSA

Personalised recommendations