Roles of Superoxide in Inflammation and Ischemic Shock

  • Joe M. McCord
Part of the Experimental Biology and Medicine book series (EBAM, volume 2)


Since the recognition in 1968 that the superoxide free radical, \(0_2^{\bar \bullet } \), could be produced by biological reactions (1), the radical has been implicated to play important roles in three pathophysiological processes: oxygen toxicity, inflammation, and post-ischemic tissue injury. The involvement of superoxide in oxygen toxicity has been elucidated by a great variety of studies involving both microbial and mammalian systems. This area has been well reviewed (2,3) and will not be further addressed in the present discussion. The major role of superoxide in the inflammatory process has recently become more clearly understood (4), while the involvement of superoxide in post-ischemic tissue injury is just beginning to unfold (5). What follows will describe our current concepts concerning the roles of superoxide in inflammation and ischemia.


Superoxide Dismutase Xanthine Oxidase Ischemic Tissue Chemotactic Factor Oxygen Toxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J. M. McCord and I. Fridovich, J. Biol. Chem., 243, 5753 (1968).PubMedGoogle Scholar
  2. 2.
    J. M. McCord and I. Fridovich, Ann. Intern. Med., 89., 122 (1978).PubMedGoogle Scholar
  3. 3.
    J. M. McCord, Rev. Biochem. Toxicol., 1 109 (1979).Google Scholar
  4. 4.
    W. F. Petrone, D. K. English, K. Wong and J. M. McCord, Proc. Natl. Acad. Sci. U.S.A., 77, 1159 (1980)PubMedCrossRefGoogle Scholar
  5. 5.
    D. N. Granger, G. Rutili and J. M. McCord, Gastroenterology, 81, 22 (1981).PubMedGoogle Scholar
  6. 6.
    J. M. McCord and I. Fridovich, J. Biol. Chem., 244, 6049 (1969).PubMedGoogle Scholar
  7. 7.
    K. B. Menander-Huber and W. Huber in “Superoxide and Superoxide Dismutases”, A. Michelson, J. McCord and I. Fridovich, Eds., Academic Press, New York, 1977, p. 537 ff.Google Scholar
  8. 8.
    B. M. Babior, R. S. Kipnes and J. T. Curnutte, J. Clin. Invest., 52., 741 (1973).PubMedCrossRefGoogle Scholar
  9. 9.
    R. B. Johnston, Jr., B. B. Keele, Jr., H. P. Misra, J. E. Lehmeyer, L. S. Webb, R. L. Baehner and K. V. Rajagopalan, J. Clin. Invest., 55, 1357 (1975).Google Scholar
  10. 10.
    J. M. McCord, Science, 195, 529 (1974).CrossRefGoogle Scholar
  11. 11.
    M. L. Salin and J. M. McCord, J. Clin. Invest., 56, 1319 (1975).PubMedCrossRefGoogle Scholar
  12. 12.
    J. M. McCord and K. Wong in “Oxygen Free Radicals and Tissue Damage” (Ciba Found. Symp. 65), Elsevier/ Excerpta Medica/North Holland, Amsterdam, 1979, p. 343 ff.Google Scholar
  13. 13.
    J. M. McCord, S. H. Stokes and K. Wong in “Advances in Inflammation Research”, Vol. 1, G. Weissmann et al., Eds., Raven Press, New York, 1979, p. 273 ff.Google Scholar
  14. 14.
    J. W. Crowell, C. E. Jones and E. E. Smith, Am. J. Physiol., 216, 744 (1969).PubMedGoogle Scholar
  15. 15.
    R. A. DeWall, K. A. Vasko, E. L. Stanley and P. Kezdi, Am. Heart. J., 82, 362 (1971).PubMedCrossRefGoogle Scholar
  16. 16.
    M. G. Battelli, E. Delia Corte and F. Stirpe, Biochem. J., 126, 747 (1972).PubMedGoogle Scholar
  17. 17.
    E. Delia Corte and F. Stirpe, Biochem. J., 126, 739 (1972).Google Scholar
  18. 18.
    R. S. Roy and J. M. McCord, J. Ala. Acad. Sci., in press.Google Scholar

Copyright information

© The Humana Press Inc. 1982

Authors and Affiliations

  • Joe M. McCord
    • 1
  1. 1.Department of Biochemistry College of MedicineUniversity of South AlabamaMobileUSA

Personalised recommendations