Roles of Superoxide in Inflammation and Ischemic Shock

  • Joe M. McCord
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 2)

Abstract

Since the recognition in 1968 that the superoxide free radical, \(0_2^{\bar \bullet } \), could be produced by biological reactions (1), the radical has been implicated to play important roles in three pathophysiological processes: oxygen toxicity, inflammation, and post-ischemic tissue injury. The involvement of superoxide in oxygen toxicity has been elucidated by a great variety of studies involving both microbial and mammalian systems. This area has been well reviewed (2,3) and will not be further addressed in the present discussion. The major role of superoxide in the inflammatory process has recently become more clearly understood (4), while the involvement of superoxide in post-ischemic tissue injury is just beginning to unfold (5). What follows will describe our current concepts concerning the roles of superoxide in inflammation and ischemia.

Keywords

Ischemia Superoxide NADH Catalase Indomethacin 

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Copyright information

© The Humana Press Inc. 1982

Authors and Affiliations

  • Joe M. McCord
    • 1
  1. 1.Department of Biochemistry College of MedicineUniversity of South AlabamaMobileUSA

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