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Control of Intercellular Communication via Gap Junctions

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Cellular Communication During Ocular Development

Part of the book series: Cell and Developmental Biology of the Eye ((EYE))

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Abstract

The gap junction is an extremely common structure which, it is generally accepted, mediates intercellular communication (cf. Bennett & Goodenough, 1977). While the function of the intercellular exchange mediated by gap junctions may be very different in various tissues, organisms and developmental stages, many of the structural, biochemical and physiological properties of gap junctions are generalizable across large phyletic distances and from one tissue to another. Gap junctions are found throughout the animal kingdom, from organisms as phylogentically primitive as porifera (thin sections: Revel & Goodenough, 1970; freeze fracture, Ginzberg & Morales, unpublished) to those as advanced as arthropods, molluscs, and higher vertebrates (cf. Staehelin, 1974). At least some cells in virtually all vertebrate organ systems are linked by gap junctions. Notable groups of cells that are not coupled include striated muscle fibers, differentiating spermatozoa, circulating erythrocytes and specific neurons (cf. Gilula, 1978; Revel, 1978). The near ubiquity of the gap junction and its evolutionary conservation imply a fundamental importance of this structure to cellular function.

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  1. D. C. Spray
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  2. A. L. Harris
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  3. M. V. L. Bennett
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  1. Department of Biology, Temple University, Philadelphia, Pennsylvania, 19122, USA

    Joel B. Sheffield  & S. Robert Hilfer  & 

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Spray, D.C., Harris, A.L., Bennett, M.V.L. (1982). Control of Intercellular Communication via Gap Junctions. In: Sheffield, J.B., Hilfer, S.R. (eds) Cellular Communication During Ocular Development. Cell and Developmental Biology of the Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5764-6_5

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