Physiological Development of Retinal Synapses

  • Ramon F. Dacheux
Conference paper
Part of the Cell and Developmental Biology of the Eye book series (EYE)


Studies which have examined the development of ganglion cell receptive fields emphasize the contrasting maturation sequence of center vs. surround organization. Initially, ganglion cell responses are dominated by the center, whereas the surround activity is either absent or very weak (Bowe-Anders et al., 1975; Rusoff and Dubin, 1977; Masland, 1977). Center-surround antagonism increases with age as the surround mechanism gradually matures and eventually achieves adult characteristics. In the rabbit this period of receptive field development occurs between 8 and 30 days of age: by 30 days of age most cells have adult receptive field properties.


Ganglion Cell Receptive Field Bipolar Cell Amacrine Cell Horizontal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Blanks, J.C., A. Adinolfi and R. Lolley. 1974. Synaptogenesis in the photoreceptor terminal of the mouse retina. J. Comp. Neurol.156: 81–93.PubMedCrossRefGoogle Scholar
  2. Bowe-Anders, C., R.F. Miller and R.F. Dacheux. 1975. Developmental characteristics of receptive organization in the isolated retina eye-cup of the rabbit. Brain Res. 87: 61–65.PubMedCrossRefGoogle Scholar
  3. Dacheux, R.F., T.E. Frumkes and R.F. Miller. 1979. Pathways and polarities of synaptic interactions in the inner retina of the mudpuppy: Synaptic blocking studies. Brain Res. 161: 1–12.PubMedCrossRefGoogle Scholar
  4. Dacheux, R.F. and R.F. Miller. 1981a. An intracellular electrophysiological study of the ontogeny of functional synapses in the rabbit retina. I. Receptors, horizontal and bipolar cells. J. Comp. Neurol. 198: 301–326.Google Scholar
  5. Dacheux, R.F. and R.F. Miller. 1981b. An intracellular electrophysiological study of the ontogeny of functional synapses in the rabbit retina. II. Receptors, horizontal and bipolar cells. J. Comp. Neurol. 198: 327–334.PubMedCrossRefGoogle Scholar
  6. DeMonasterio, F.M. 1978. Spectral interactions in horizontal and ganglion cells of the isolated and arterially perfused rabbit retina. Brain Res. 150: 239–258.CrossRefGoogle Scholar
  7. Kaneko, A. 1970. Physiological and morphological identification of horizontal, bipolar and amacrine cells in goldfish retina. J. Physiol. (Lond.) 207: 623–633.Google Scholar
  8. Masland, R.H. 1977. Maturation of function in developing rabbit retina. J. Comp. Neurol. 175: 275–286.PubMedCrossRefGoogle Scholar
  9. McArdle, C.B., J.E. Dowling and R.H. Masland. 1977. Development of outer segments and synapses in the rabbit retina. J. Comp. Neurol. 175: 253–274.PubMedCrossRefGoogle Scholar
  10. Miller, R.F. and R.F. Dacheux. 1973. Information processing in the retina: Importance of chloride ions. Science 181: 266–268.PubMedCrossRefGoogle Scholar
  11. Miller, R.F. and R.F. Dacheux. 1976a. Synaptic organization and ionic basis of “on” and “off” channels in the mudpuppy retina. III. A model of ganglion cell receptive field organization based on chloride free experiments. J. Gen. Physiol. 67: 679–690.PubMedCrossRefGoogle Scholar
  12. Miller, R.F. and R.F. Dacheux. 1976b. Dendritic and somatic spikes in mudpuppy amacrine cells: Identification and TTX sensitivity. Brain Res. 104: 157–162.PubMedCrossRefGoogle Scholar
  13. Naka, K.I. 1976. Neuronal circuitry in the catfish retina. Invest. Ophthalmol. 15: 926–935.Google Scholar
  14. Nelson, R. 1977. Cat cones have rod input: A comparison of the response properties of cones and horizontal cell bodies in the retina of the cat. J. Comp. Neurol. 172: 109–136.PubMedCrossRefGoogle Scholar
  15. Noell, W.K. 1958. Differentiation, metabolic organization and viability of the visual cell. Arch. Ophthalmol. 60: 702–733.Google Scholar
  16. Richter, A. and E.J. Simon. 1975. Properties of center hyperpolarizing, red-sensitive biopolar cells in the turtle retina. J. Physiol. (Lond.) 248: 317–334.Google Scholar
  17. Rusoff, A. and M. Dubin. 1977. Development of receptive field properties of retinal ganglion cells in kitten. J. Neurophysiol. 40: 1188–1198.PubMedGoogle Scholar
  18. Steinberg, R.H. 1969. The rod after-effect in S-potentials from the cat retina. Vision Res. 9: 1345–1355.PubMedCrossRefGoogle Scholar
  19. Werblin, F.S. 1977. Synaptic interactions mediating bipolar responses in the retina of the tiger salamander. In “Vertebrate Photoreception” (Barlow and Fatt, eds.) London: Academic Press, pp. 205–230.Google Scholar
  20. Werblin, F.S. and J.E. Dowling. 1969. Organization of the retina of the mudpuppy Necturus maculosus: II. Intracellular recording. J. Neurophysiol. 32: 339–355.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1982

Authors and Affiliations

  • Ramon F. Dacheux

There are no affiliations available

Personalised recommendations