Hypertension and Arteriosclerosis

  • G. Schettler
  • H. U. Comberg


According to Doerr,10–12 arteriosclerosis develops only when suitable conditions exist. These are de-fined first by a vascular wall factor; second, by a so-called general factor, meaning the hemodynamic and humoral load on the vascular wall; and third, by a barrier factor. The latter is responsible for plasma infiltration and leads to further transformation of the vascular wall. Doerr is of the opinion that fat accumulation in the plasma, as in nutrition atheroma, leads in humans to the so-called storage xanthomatosis, but not to atherosclerosis. Furthermore, according to Doerr, a simple elevation of blood pressure without any general metabolic disorder does not cause arteriosclerosis. A slight relaxation of the internal stability of the arteries would have to be present. More intense forms of sclerosis ensue only if several factors coexist.


Diastolic Blood Pressure Antihypertensive Therapy Mild Hypertension Malignant Hypertension Hypertension Detection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ames RP, Hill P (1976) Elevation of serum lipids during diuretic therapy of hypertension. Am J Med 61: 748–752PubMedCrossRefGoogle Scholar
  2. 2.
    Anitschkow N (1913) Über die Veränderungen der Kaninchenaorta bei experimenteller Cholesterinsteatose. Beitr Pathol Anat 56: 379–404Google Scholar
  3. 3.
    Anitschkow N (1933) Experimental arteriosclerosis in animals. In: Cowdry EV (ed) Arteriosclerosis. Macmillan, New York, p 271–322Google Scholar
  4. 4.
    Baumgartner HR (1977) Zur Pathogenese der Atherosklerose. In: Internationales Symposium in Wien. Der Herzinfarkt. Schattauer, Stuttgart, New York, pp. 91–102Google Scholar
  5. 5.
    Bennhold H (1931) Über die Bindung des Cholesterins an die Globuline; zugleich ein weiterer Beitrag zur Frage der Funktion der Serumeiweiβkörper. Verh Dtsch Ges Inn Med 43: 211–213Google Scholar
  6. 6.
    Berkson DM, Stamler J (1965) Epidemiological findings on cerebrovascular diseases and their implications. J Atheroscler Res 5: 189–202PubMedCrossRefGoogle Scholar
  7. 7.
    Breckenridge A, Dollery CT, Parry EH (1970) Prognosis of treated hypertension. Changes in life expec-tancy and causes of death between 1952 and 1967. Q J Med 39: 411–429PubMedGoogle Scholar
  8. 8.
    Build and Blood Pressure Study (1959) vol 1. Society of Actuaries, Chicago.Google Scholar
  9. 9.
    Dengler HJ, Schettler G (1965) Hochdruck und Herzinfarkt. Naturwiss Med 7: 52–60Google Scholar
  10. 10.
    Doerr W (1963) Perfusionstheorie der Arteriosklerose. Thieme, StuttgartGoogle Scholar
  11. 11.
    Doerr W (1970) Allgemeine Pathologie der Organe des Kreislaufs. In: Büchner F, Letterer E, Roulet CF (eds)Handbuch der Allgemeinen Pathologie, Bd III/ 4. Springer, Berlin, Heidelberg, New York, p. 205Google Scholar
  12. 12.
    Doerr W (1976) Initiale zelluläre Vorgänge bei Atherosklerose und Hypertonie. Atherogenese 1: 79–87Google Scholar
  13. 13.
    Duguid JB (1946) Thrombosis as a factor in the pathogenesis of coronary atherosclerosis. J Pathol Bact 58: 207–212CrossRefGoogle Scholar
  14. 14.
    Duguid JB (1955) Mural thrombosis in arteries. Br Med Bull 11: 36–38PubMedGoogle Scholar
  15. 15.
    Duguid JB (1960) The thrombogenic hypothesis and its implications. Postgrad Med J 36: 226–229PubMedCrossRefGoogle Scholar
  16. 16.
    Farmer RG, Giiford RW, Hines EH (1963) Effect of medical treatment of severe hypertension. Arch Intern Med 112: 118–128PubMedGoogle Scholar
  17. 17.
    Gofman JW, Jones HB, Strisower B, Tamplin AR (1956) Evaluation of serum lipoproteins and cholesterol measurements as predictors of clinical complications of atherosclerosis. Report of a cooperative study of lipoproteins and atherosclerosis. Appendix A. Circulation 14: 725–731Google Scholar
  18. 18.
    Gofman JW, Tamplin AR, Strisower B (1954) Relation of fat and caloric intake to atherosclerosis. J Am Diet Assoc 30: 317–326PubMedGoogle Scholar
  19. 19.
    Gofman JW, Young W (1963) The filtration concept of atherosclerosis. In: Sandler M, Bourne GH (eds) Atherosclerosis and its origin. Academic Press, New York, pp. 197–229Google Scholar
  20. 20.
    Goldberg AD, Raftery EB (1976) Patterns of blood-pressure during chronic administration of postganglionic sympathetic blocking drugs for hypertension. Lancet 11: 1052–1054CrossRefGoogle Scholar
  21. 21.
    Goldstein JL, Brown MS (1975) Lipoprotein receptors, cholesterol metabolism and atherosclerosis. Arch Pathol 99: 181–184PubMedGoogle Scholar
  22. 22.
    Goldstein JL, Dana SE, Brown MS (1974) Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia. Proc Natl Acad Sei USA 71: 4288–4292CrossRefGoogle Scholar
  23. 23.
    Greten H (1969) Diagnose und Differenzierung von Hyperlipoproteinämien. Klin Wochenschr 47: 893–896PubMedCrossRefGoogle Scholar
  24. 24.
    Hany A, Schaub F, Nager F (1965) Die Prognose der behandelten malignen Hypertonie. Dtsch Med Wochenschr 90: 18–26PubMedCrossRefGoogle Scholar
  25. 25.
    Haust MD, More RH (1958) New functional aspects of smooth muscle cells. Fed Proc 17: 440Google Scholar
  26. 26.
    Haust MD, More RH, Movat HZ (1960) The role of smooth muscle cells in the fibrogenesis of atherosclerosis. Am J Pathol 37: 377–389PubMedGoogle Scholar
  27. 27.
    Heath D, Wood EH, Dushane JW, Edwards JE (1960) The relation of age and blood pressure to atheroma in the pulmonary arteries and the thoracic aorta in congenital heart disease. Lab Invest 9: 259–272PubMedGoogle Scholar
  28. 28.
    Heyden S (1974) Risikofaktoren für das Herz. Boehringer GmbH, Mannheim, p. 10Google Scholar
  29. 29.
    Heyden S, Bartel AG, Hames CG, McDonough JR (1969) Elevated blood pressure levels in adolescents. JAMA 209: 1683–1689PubMedCrossRefGoogle Scholar
  30. 29a.
    Hypertension Detection and Follow-up Program Cooperative Group (1979) Five-year findings of the hypertension detection and follow-up program. L Reduction in mortality of persons with high blood pressure, including mild hypertension. IL Mortality by race, sex and age. JAMA 242: 2562–2577CrossRefGoogle Scholar
  31. 30.
    Inter-Society Commission for Heart Disease Resources (1970) Atherosclerosis Study Group: Primary prevention of atherosclerotic diseases. Circulation 42: A55–A95Google Scholar
  32. 31.
    Kannel WB, Widmer LK, Dawber TR (1965) Gefährdung durch coronare Herzkrankheit. Schweiz Med Wochenschr 95: 18–24PubMedGoogle Scholar
  33. 32.
    Keith NM, Wagner HP, Barker NM (1939) Some different types of essential hypertension: their course and prognosis. Am J Med Sci 197: 332–343CrossRefGoogle Scholar
  34. 33.
    Leishman AW (1963) Merits of reducing high blood pressure. Lancet 1: 1284–1288PubMedCrossRefGoogle Scholar
  35. 34.
    Macheboeuf MA (1929) Recherches sur les phosphoaminolipides et les stérides du serum et du plasma sanguins; entraînement des phospholipides, des stérides par les diverses fractions au cours du fractionnement des protéides du serum. Bull Soc Chem Biol 11: 268–293Google Scholar
  36. 35.
    Mustard JF, Packham MA, Moore S, Kinlough-Rathbone RL (1974) Thrombosis and atherosclerosis. In: Schettler G, Weizel A (eds) Atherosclerosis III—Proceedings of the Third International Symposium. Springer, Berlin, Heidelberg, New York, pp 253–267Google Scholar
  37. 36.
    Mustard JF, Packham MA (1975) Platelets, thrombosis and drugs. Drugs 9: 19–76PubMedCrossRefGoogle Scholar
  38. 37.
    Mustard JF, Rowsell HC, Murphy EA, Downie HG (1963) Intimal thrombosis in atherosclerosis. In: Jones RJ (ed) Evolution of the atherosclerotic plaque. Chicago University Press, Chicago, pp 183–203Google Scholar
  39. 38.
    Rokitansky C (1852) A manual of pathological anatomy, vol 4, p 261. Translated by GE Day. Sydenham Society, LondonGoogle Scholar
  40. 39.
    Rokitansky C (1844) Handbuch der pathologischen Anatomie, Bd II. Braumüller und Seidel, Wien, p. 534.Google Scholar
  41. 40.
    Ross R, Glomset J, Kraiya B, Harker L (1974) A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sei USA 71: 1207 - 1210CrossRefGoogle Scholar
  42. 41.
    Schettler G (1961) Arteriosklerose. Thieme, StuttgartGoogle Scholar
  43. 42.
    Schettler G (1977) Das Arterioskleroseproblem. Dtsch Ärztebl 74: 735–742Google Scholar
  44. 43.
    Schettler G, Boyd GS (1969) Atherosclerosis. Elsevier, AmsterdamGoogle Scholar
  45. 44.
    Schettler G, Dietrich F, Eggstein M (1955) Lipid-und Lipoproteinspektrum bei Koronarkranken jugendlichen und mittleren Alters. Verh Dtsch Ges Kreislaufforsch 21: 124–130Google Scholar
  46. 45.
    Seidel D (1973) Plasmalipoproteine: Biochemische und klinische Aspekte. Münch Med Wochenschr 115: 613–619Google Scholar
  47. 46.
    Smith WM (1977) Treatment of mild hypertension. Results of a ten-year intervention trial. U.S. Public Health Service Hospitals Cooperative Study Group. Circ Res [Suppl 1] 40: 98–105Google Scholar
  48. 47.
    Stamler J (1957) Problems of the research utilization of vital statistics on the cardiovascular and renal diseases. Report submitted to the Chicago Heart Association on morbidity and mortality classification of cardiovascular disorders. Chicago Heart Association, ChicagoGoogle Scholar
  49. 48.
    Stamler J (1967) Lectures on preventive cardiology. Grune and Stratton, New YorkGoogle Scholar
  50. 49.
    Stamler J (1974) The primary prevention of coronary heart disease. In: Braunwald (ed) The myocardium: Failure and infarction. HP Publishing Co., New York, pp 219–236Google Scholar
  51. 50.
    Stewart I, McD G (1971) Long-term observations on high blood-pressure presenting in fit young men. Lancet 1: 355–358PubMedCrossRefGoogle Scholar
  52. 51.
    Stewart I, McD G (1976) Compared incidence of first myocardial infarction in hypertensive patients under treatment containing Propranolol or excluding ß-receptor blockade. Clin Sci Mol Med [Suppl 3] 51: 509s–511sGoogle Scholar
  53. 52.
    Veterans Administration Cooperative Study Group on Antihypertensive Agents (1967) Eflfects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressure averaging 115 through 129 mm Hg. JAMA 202: 1028–1034CrossRefGoogle Scholar
  54. 53.
    Veterans Administration Cooperative Study Group on Antihypertensive Agents (1970) Effects of treatment on morbidity in hypertension: II: Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. JAMA 213: 1143–1152CrossRefGoogle Scholar
  55. 54.
    Walton KW, Williamson N, Johnson AG (1970) The pathogenesis of atherosclerosis of the mitral and aortic valves. J Pathol 101: 205–220PubMedCrossRefGoogle Scholar
  56. 55.
    Wissler RW (1974) Development of the atherosclerotic plaque. In: Braunwald E (ed) The myocardium: Failure and infarction. HP Publishing Co, New York, pp. 155–166Google Scholar
  57. 56.
    Writing Committee on behalf of the HDFP Cooperative Group (1976) The Hypertension Detection and Follow-Up Program. Prev Med 5: 207–215CrossRefGoogle Scholar
  58. 57.
    The Management Committee (1980) The Australian therapeutic trial in mild hypertension. Lancet I: 1261–1267.Google Scholar

Copyright information

© Springer-Verlag New York, Inc. 1982

Authors and Affiliations

  • G. Schettler
  • H. U. Comberg

There are no affiliations available

Personalised recommendations