The synergism that usually results when two or more antihypertensive drugs are administered concurrently has effects in two directions: On the one hand, the phenomenon allows different antihypertensive drugs to be administered in a lower dose than during monotherapy, thereby reducing their toxicity. On the other hand, the concurrent administration of several antihypertensive drugs can easily lead to an excessive fall of blood pressure.
KeywordsAntihypertensive Drug Antihypertensive Drug Therapy Ethacrynic Acid Potassium Deficiency Storage Vesicle
- 5.Goodman LS, Gilman A (eds) (1975) The Pharmacological Basis of Therapeutics, 5th ed. Macmillan, New YorkGoogle Scholar
- 6.Hansten PD (1974) Arzneimittel-Interaktionen. Hippokrates, StuttgartGoogle Scholar
- 9.Martin EW (1971) Hazards of Medication. Lippincott, PhiladelphiaGoogle Scholar
- 12.Nickerson M, Collier B (1975) Drugs inhibiting adrenergic nerves and structures innervated by them. In: Goodman LS, Gilman A (eds) The Pharmacological Basis of Therapeutics, 5th ed. Macmillan, New York, pp 549–584Google Scholar