Systolic Hypertension in the Elderly: A Therapeutic Problem

  • A. V. Chobanian


Systolic hypertension in the elderly is a common clinical problem which represents a major therapeutic dilemma. The magnitude of the problem is increasing as the population of individuals over 50 years of age is expanding. Recent epidemiologic studies have suggested that systolic hypertension is an important risk factor for several major cardiovascular complications. However, the merits of treatment for the disorder remain obscure, and the optimum approach for lowering blood pressure has not been defined clearly. This paper will review some of the available information on this subject and will offer a personal approach to its management.


Systolic Blood Pressure Orthostatic Hypotension Antihypertensive Therapy Beta Blocker Systolic Hypertension 
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  1. 1.
    Abboud FM, Huston JH (1961) The effects of aging and degenerative vascular disease on the measurement of arterial rigidity in man. J Clin Invest 40: 933–939PubMedCrossRefGoogle Scholar
  2. 2.
    Blood pressure of adults by race and area, United States 1960–1962. National Health Survey, series 11, number 5, 1964Google Scholar
  3. 3.
    Colandrea MA, Friedman GD, Nichaman MA, Lynd CN (1970) Systolic hypertension in the elderly: an epidemiologic assessment. Circulation 41: 239–245PubMedGoogle Scholar
  4. 4.
    Conway J (1961) Arteriosclerotic hypertension. In: Brest AN, Moyer JH (eds) Hypertension-Recent Advances: Second Hahneman Symposium on Hypertensive Disease. Lea & Febiger, Philadelphia, p 577Google Scholar
  5. 5.
    Dyer AR, Stamler J, Shekelle RB, et al. (1977) Hypertension in the elderly. Med Clin N Amer 61: 513–529PubMedGoogle Scholar
  6. 6.
    Hruza Z (1973) Catabolism of epinephrine and histamine during aging in rats. Ext Gerontol 8: 333–336CrossRefGoogle Scholar
  7. 7.
    Hruza Z, Zweifach BW (1967) Effect of age on vascular reactivity to catecholamines in rats. J Gerontol 22: 469–473PubMedGoogle Scholar
  8. 8.
    Jackson G, Mahon W, Pierscianowski TA, Condon J (1976) Inappropriate antihypertensive therapy in the elderly. Lancet 2: 1317–1318PubMedCrossRefGoogle Scholar
  9. 9.
    Kannel WB, Wolf PA, Verter J, et al. (1970) Epidemiologic assessment of the role of blood pressure in stroke: The Framingham Study. JAMA 214: 301–310PubMedCrossRefGoogle Scholar
  10. 10.
    Kannel WB, Gordon T, Schwartz MJ (1971) Systolic versus diastolic blood pressure and risk of coronary heart disease: The Framingham Study. Am J Cardiol 27: 335–346PubMedCrossRefGoogle Scholar
  11. 11.
    Kannel WB, Castelli WP, McNamara P, et al. (1972) Role of blood pressure in the development of congestive heart failure: The Framingham Study. N Engl J Med 287: 781–787PubMedCrossRefGoogle Scholar
  12. 12.
    Lake CR, Ziegler MG, Coleman MD, Kopin JK (1977) Age-adjusted plasma norepinephrine levels are similar in normotensive and hypertensive subjects. N Engl J Med 296: 208–209PubMedCrossRefGoogle Scholar
  13. 13.
    Woods JW, Pittman AW, Pulham CC, et al. (1976) Renin profiling in hypertension and its use in treatment with propranolol and chlorthalidone. N Engl J Med 294: 1137–1143PubMedCrossRefGoogle Scholar

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© Springer-Verlag New York, Inc. 1982

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  • A. V. Chobanian

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