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Central Hemodynamics and Cardiac Function in Hypertension

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Arterial Hypertension
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Abstract

Despite the tremendous volume of information published on the mechanisms of hypertension, the details of the pathophysiologic relationships are not yet clearly understood. Many questions remain unanswered. In this article we shall attempt to review current knowledge on the dynamics of blood flow in the central region of the circulation, as well as on the dynamics of cardiac funtion.

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References

  1. Amery A, Julius S, Whitlock LS, Conway J (1967) Influence of hypertension on the hemodynamic response to exercise. Circulation 36: 231

    PubMed  CAS  Google Scholar 

  2. Bing RJ (1951) The coronary circulation in health and disease as studied by sinus catheterization. Bull NY Acad Med 27: 407

    CAS  Google Scholar 

  3. Birkenhäger WH, Es LA van, Honwing A (1968) Studies on the lability of hypertension in man. Clin Sci 35: 445

    PubMed  Google Scholar 

  4. Bretschneider HJ (1967) Aktuelle Probleme der Koronardurchblutung und des MyokardstofFwechsels. Regensburg Ärztl Fortbild 1: 11

    Google Scholar 

  5. Brod J (1960) Essential hypertension. Hemodynamic observations with a bearing on its pathogenesis. Lancet II: 773

    Google Scholar 

  6. Brod J, Fend V, Stejl Z, Jirka J, Ulrych M (1962) General and regional haemodynamic patterns underlying essential hypertension. Clin Sci 23: 339

    PubMed  CAS  Google Scholar 

  7. Bürger S, Strauer BE (1977) Ventrikelfunktion und Kontraktilitätsreserve bei der spontanen essentiellen Hypertonie der Ratte. Verh Dtsch Oes Kreislaufforsch 43: 259

    Google Scholar 

  8. Bürger S, Meinardus A, Strauer BE (1978) Hyper- trophiegrad und Dynamik des linken Ventrikels bei der spontanen essentiellen Hypertonie der Ratte. Klin Wochenschr 56: 207

    Article  PubMed  Google Scholar 

  9. Cohn JN (1973) Blood pressure and cardiac performance. Am J Med 55: 351

    Article  PubMed  CAS  Google Scholar 

  10. Cohn JN, Rodriguera E, Guiha NH (1973) Left ventricular function in hypertensive heart disease. In: Onesti G, Kim KE, Moyer JH (eds) Hypertension: Mechanisms and Management. Grune & Stratton, New York, London, p 191

    Google Scholar 

  11. Distler A, Just H, Philipp Th (1973) Studies on the mechanism of aldosterone-induced hypertension in man. Clin Sei Mol Med 45: 743

    CAS  Google Scholar 

  12. Dittrich J, Rexroth W, Stein U, Spaan G, Wagner E (1977) Hypertensive Herzerkrankung. Inn Med 4: 177

    Google Scholar 

  13. Eich RH, Peters RI, Cuddy RP, Smulyan H, Lyons RH (1962) The hemodynamics in labile hypertension. Am Heart J 63: 188

    Article  PubMed  CAS  Google Scholar 

  14. Finkielman S, Worcel M, Agrest A (1965) Hemodynamic patterns in essential hypertension. Circulation 31: 356

    PubMed  CAS  Google Scholar 

  15. Ford LE (1976) Heart size. Circ Res 39: 297

    CAS  Google Scholar 

  16. Frank S, Braunwald E (1968) Idiopathic hypertrophic subaortic stenosis. Clinical analysis of 126 patients with emphasis on the natural history. Circulation 37: 759

    PubMed  CAS  Google Scholar 

  17. Fröhlich E (1973) Clinical-physiologic classification of hypertensive heart disease in essential hypertension. In: Onesti G, Kim KE, Moyer JH (eds) Hypertension: Mechanisms and Management. Grune & Stratton. New York, London, p 181

    Google Scholar 

  18. Fröhlich E (1977) Hemodynamics of hypertension. In: Genest J, Koiw E, Kuchel 0 (eds) Hypertension. McGraw-Hill, New York, p 15

    Google Scholar 

  19. Fröhlich E, Tarazi RC, Dustan HP (1969) Hyperdynamic β-adrenergic circulatory state: Increased ß- receptor responsiveness. Arch Intern Med 123: 1

    Google Scholar 

  20. Fröhlich E, Tarazi RC, Dustan HP (1971) Clinical- physiological correlations in the development of hypertensive heart disease. Circulation 44: 446

    PubMed  Google Scholar 

  21. Fröhlich E, Tarazi RC, Ulrych M, Dustan HP, Page IH (1967) Tilt test for investigating a neural component in hypertension. Circulation 36: 387

    PubMed  Google Scholar 

  22. Gaasch WH, Quinones MA, Weisser E, Thiel HG, Alexander JK (1976) Diastolic compliance of the left ventricle in man. Am J Cardiol 38: 645

    Article  PubMed  CAS  Google Scholar 

  23. Genest J, Koiw E, Kuchel 0 (eds) (1977) Hypertension. McGraw-Hill, New York

    Google Scholar 

  24. Grossman W, McLaurin LP, Moos SP, Stefadouros M, Young DT (1974) Wall thickness and diastolic properties of the left ventricle. Circulation 49: 129

    PubMed  CAS  Google Scholar 

  25. Guyton AC (1977) Personal views on mechanisms of hypertension. In: Genest J, Koiw E, Kuchel 0 (eds) Hypertension. McGraw-Hill, New York 1977, p 536

    Google Scholar 

  26. Hood WP (1971) Dynamics of hypertrophy in left ventricular wall of man. In: Alpert NR (ed) Cardiac Hypertrophy. Academic Press, London, New York, p445

    Google Scholar 

  27. Hood WP, Rackley ChE, Rolett EL (1968) Wall stress in the normal and hypertrophied left ventricle. Am J Cardiol 22: 550

    Article  PubMed  Google Scholar 

  28. Hood WP, Thomson WJ, Rackley ChE, Rolett EL (1969) Comparison of calculation of left ventricular wall stress in man from thin-walled and thick- walled elipsoidal models. Circ Res 24: 575

    PubMed  Google Scholar 

  29. Hugenholtz PG, Kaplan E, Hull E (1969) Determination of left ventricular wall thickness by angiocardiography. Am Heart J 78: 513

    Article  PubMed  CAS  Google Scholar 

  30. James TH (1977) Small arteries of the heart. Circulation 56: 2

    PubMed  CAS  Google Scholar 

  31. James TH, Isobe JH, Urthaler (1975) Analysis of components in a cardiogenic hypertensive chemo- reflex. Circulation 52: 179

    CAS  Google Scholar 

  32. Julius S, Amery A, Whitlock LS, Conway J (1967) Influence of age on the hemodynamic response to exercise. Circulation 36: 222

    PubMed  CAS  Google Scholar 

  33. Julius S, Conway J (1968) Hemodynamic studies in patients with borderline blood pressure elevation. Circulation 38: 282

    PubMed  CAS  Google Scholar 

  34. Julius S, Pascual AV, Loudon R (1971) Role of parasympathetic inhibition in hyperkinetic type of borderline hypertension. Circulation 44: 413

    PubMed  CAS  Google Scholar 

  35. Julius S, Pascual AV, Sannerstedt R, Mitchell C (1971) Relationship between cardiac output and peripheral resistance in borderline hypertension. Circulation 43: 382

    PubMed  CAS  Google Scholar 

  36. Just H, Horbach L, Nicolescu RF, Rosenthal J, Brod J, Wolff HP (1973) Veränderungen der Hämodynamik und Reninaktivität bei physiologischer Orthostase. Cardiol Bull 6: 191

    Google Scholar 

  37. Kahlstorf A (1933) Über Korrelationen der linearen Herzma ße und des Herzvolumens. Klin Wschr 12: 262.

    Article  Google Scholar 

  38. Kannel WB, Dawber TR (1973) Hypertensive cardiovascular disease. The Framingham Study. In: Onesti G, Kim KE, Moyer JH (eds) Hypertension: Mechanisms and Management. Grune & Stratton, New York, London, p 93

    Google Scholar 

  39. Kathke N (1966) Veränderungen der Koronararte- rienzweige des Myokards bei Hypertonie. Beitr Path Anat 115: 405

    Google Scholar 

  40. Keith NM, Wagener HP, Barker NW (1939) Some different types of essential hypertension; their course and prognosis. Am J Med Sci 197: 332

    Article  Google Scholar 

  41. Kennedy JW, Baxley WA, Figley MM, Dodge HT, Blackmon JR (1966) Quantitative angiocardiography: I. The normal left ventricle in man. Circulation 34: 272

    Google Scholar 

  42. Kochsiek K, Tauchert M, Cott L, Neubaur J (1970) Die Koronarreserve bei Patienten mit Aortenvitien. Verh Dtsch Ges Inn Med 76: 214

    Google Scholar 

  43. Kochsiek K, Larbig D, Harmjanz D (1971) Die hypertrophische obstruktive Kardiomyopathie. (Experimentelle Medizin, Pathologie und Klinik, Bd. 35 ) Springer, Berlin, Heidelberg, New York

    Google Scholar 

  44. Limbourg P, Fiegel P, Just H, Lang KF (1974) Kreislaufumstellung und Funktion der linken Kammer während isometrischer Belastung bei Hochdruckkranken. In: Distler A, Wolff HP (eds) Hypertension. Thieme, Stuttgart, p 200

    Google Scholar 

  45. Limbourg P, Just H, Lang KF, Schölmerich P (1976) Ventricular function at rest and during exercise in the hypertensive heart. In: Roskamm H, Hahn Ch (eds) Ventricular Function and Rest during Exercise. Springer, Berlin, Heidelberg, New York, pp 83–86

    Google Scholar 

  46. Linzbach A J (1960) Heart failure from the point of view of quantitative anatomy. Am J Cardiol 5: 370

    Article  PubMed  CAS  Google Scholar 

  47. Linzbach AJ, Linzbach M (1951) Die Herzdilatation. Klin Wochenschr 29: 40

    Article  Google Scholar 

  48. Lochner W (1971) Herz. In: Bauereisen E (ed) Physiologie des Kreislaufes, Bd I. Lehrbuch der Physiologie in Einzeldarstellungen. Springer, Berlin, Heidelberg, New York, pp 185–228

    Google Scholar 

  49. Lund-Johansen P (1967) Hemodynamics in early essential hypertension. Acta Med Scand (Suppl. 1 ) 183: 482

    Google Scholar 

  50. Meerson FS (1969) Hyperfunktion, Hypertrophie und InsuflSzienz des Herzens. VEB Volk und Gesundheit, Berlin

    Google Scholar 

  51. Okamoto K (1972) Spontaneous Hypertension. Springer, Berlin, Heidelberg, New York

    Google Scholar 

  52. Onesti G, Kim KE, Moyer HJ (eds) (1973) Hypertension: Mechanisms and Management. Grune & Stratton, New York, London

    Google Scholar 

  53. Page LB, Yager HM, Sidd JJ (1976) Drugs in the management of hypertension. Am Heart J 92: 252

    Article  PubMed  CAS  Google Scholar 

  54. Riecker G, Bolte HD, Lüderitz B, Strauer BE (1978) Ätiologische und pathophysiologische Grundlagen des akuten Myokardversagens. Verh Dtsch Ges Kreislaufforsch 44:

    Google Scholar 

  55. Rohter F (1916/1917) Volumenbestimmungen an Herzhöhlen und Organen auf orthodiagraphischem Wege. Fortschr Röntgenstr 24:285.

    Google Scholar 

  56. Ross J Jr, Sonnenblick EH, Convelí JW, Kaiser CA, Spiro D (1967) The architecture of the heart in systole and diastole. Circ Res. 21: 40

    Google Scholar 

  57. Rowe GG, Castillo CA, Maxwell GM, Crumpton ChW (1961) A hemodynamic study of hypertension including observations in coronary blood flow. Ann Intern Med 54: 405

    PubMed  CAS  Google Scholar 

  58. Sannerstedt R (1966) Hemodynamic response to exercise in patients with arterial hypertension. Acta Med Scand (Suppl.) 180: 458

    Google Scholar 

  59. Sannerstedt R (1969) Hemodynamic findings at rest and during exercise in mild arterial hypertension. Am J Med Sci 258: 70

    Article  PubMed  CAS  Google Scholar 

  60. Scherpe A, Strauer BE (1976) Untersuchungen über die hämodynamischen Determinanten der Auswurffraktion des Herzens. Verh Dtsch Ges Inn Med 82: 1109

    PubMed  CAS  Google Scholar 

  61. Spann JF, Buccino RA, Sonnenblick EH, Braunwald E (1967) Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure. Circ Res 21: 341

    PubMed  Google Scholar 

  62. Strauer BE (1975) Dynamik, Koronardurchblutung und Sauerstoifverbrauch des normalen und kranken Herzens. Karger, Basel

    Google Scholar 

  63. Strauer BE (1975) Die hypertrophische obstruktive Kardiomyopathie. Internist 16: 530

    PubMed  CAS  Google Scholar 

  64. Strauer BE (1976) Änderungen der Kontraktilität bei Druck- und Volumenbelastungen des Herzens. Verh Dtsch Ges Kreislauiforsch 42: 69

    Google Scholar 

  65. Strauer BE (1977) Ventrikelfunktion und koronare Hämodynamik bei der essentiellen Hypertonie. Verh Dtsch Ges Kreislauiforsch 43: 41

    CAS  Google Scholar 

  66. Strauer BE (1978) Das Hochdruckherz: I. Funktion des linken Ventrikels in Ruhe und unter körperlicher Belastung. Z Kardiol 67: 375

    PubMed  CAS  Google Scholar 

  67. Strauer BE (1978) Das Hochdruckherz: II. Koronardurchblutung, Koronarreserve und Sauer- stoflfverbrauch des linken Ventrikels. Z Kardiol 67: 452

    PubMed  CAS  Google Scholar 

  68. Strauer BE (1978) Das Hochdruckherz: III. Determinanten der linksventrikulären Hypertrophie und linksventrikulären Dehnbarkeit. Z Kardiol 67: 513

    PubMed  CAS  Google Scholar 

  69. Strauer BE (1978) Das Hochdruckherz: IV. Regionaler Hypertrophiegrad und Proportionalität der Ventrikelwandhypertrophie. Z Kardiol 67: 601

    PubMed  CAS  Google Scholar 

  70. Strauer BE, Bürger S (1978) Das Hochdruckherz: V. Masse-Volumen-Relation, Wandspannungen und Hypertrophiegrad: Diagnostische und therapeutische Konsequenzen. Z Kardiol 67: 653

    Google Scholar 

  71. Strauer BE (1978) Das Hochdruckherz: VI. Ventrikelfunktion und koronare Hämodynamik unter dem EinflujS von Digitalisglykosiden. Dtsch Med Woch- enschr 103: 1691

    Article  CAS  Google Scholar 

  72. Strauer BE (1978) Das Hochdruckherz: VII. Die Wirkung von Beta-Rezeptorenblockern (Atenolol) auf Funktion, koronare Hämodynamik und Sauerstoifverbrauch des linken Ventrikels. Dtsch Med Wochenschr 103: 1785

    Article  PubMed  CAS  Google Scholar 

  73. Strauer BE (1977) Neuere Ergebnisse zur Patho- physiologie der Koronarinsuffizienz. Internist 18: 294

    PubMed  CAS  Google Scholar 

  74. Strauer BE (1980) Hypertensive Heart Disease. Springer, Berlin, Heidelberg, New York

    Google Scholar 

  75. Strauer BE, Beer K, Keitlinger K, Höfling B (1977) Left ventricular systolic wall stress as a primary determinant of myocardial oxygen consumption: Comparative studies in patients with normal left ventricular function, with pressure and volume overload and with coronary heart disease. Basic Res Cardiol 72: 306

    Google Scholar 

  76. Strauer BE, Brune J, Schenk H, Knoll D, Perings E (1976) Lupus cardiomyopathy. Cardiac mechanics, hemodynamics and coronary blood flow in uncomplicated systemic lupus erythematosus. Am Heart J 92: 715

    Google Scholar 

  77. Strauer BE (1979) Ventricular function and coronary hemodynamics in hypertensive heart disease. Amer J Cardiol 44: 999

    Article  PubMed  CAS  Google Scholar 

  78. Strauer BE (1979) Myocardial oxygen consumption in chronic heart disease: Role of wall stress, hypertrophy and coronary reserve. Amer J Cardiol 44: 731

    Google Scholar 

  79. Tarazi RC, Fouad FM (1978) Hemodynamic characteristics in hypertension. Herz 3: 245

    PubMed  CAS  Google Scholar 

  80. Tauchert M (1973) Koronarreserve und maximaler Sauerstoifverbrauch des menschlichen Herzens. Basic Res Cardiol 68: 183

    Article  PubMed  CAS  Google Scholar 

  81. Taylor SH, Donald KW, Bishop JB (1957) Circulatory studies in hypertensive patients at rest and during exercise. Clin Sci 16: 351

    PubMed  CAS  Google Scholar 

  82. Varnauskas E (1955) Studies in hypertensive cardiovascular disease with special reference to cardiac function. Scand J Clin Lab Invest (Suppl. 17 ) 7: 17

    Google Scholar 

  83. Vaughan Williams EM, Raine AEG, Cabrera HA, Whyte JM (1975) The effects of prolonged beta-ad- renoreceptor blockade on heart size and cardiac intracellular potentials in rabbits. Cardiovasc Res 9: 579

    Article  Google Scholar 

  84. Völker W, Strauer BE, Riecker G (1972) Die maximale Verkürzungsgeschwindigkeit (Vmax) am hyper- trophierten linken Ventrikel des Meerschweinchens beim Goldblatt-Hochdruck. Verh Dtsch Ges Kreislauiforsch 38: 161

    Google Scholar 

  85. Wallace JM (1975) Hemodynamic lesions in hypertension. Am J Cardiol 36: 670

    Article  PubMed  CAS  Google Scholar 

  86. Weiss L, Lundgren Y, Folkow B (1974) Eifects of prolonged treatment with adrenergic betareceptor antagonists on blood pressure, cardiovascular design and reactivity in spontaneously hypertensive rats ( SHR ). Acta Physiol 91: 447

    Google Scholar 

  87. Wezler K, Böger A (1939) Die Dynamik des arteriellen Systems. Der arterielle Blutdruck und seine Komponenten. Ergebn Physiol 41: 292

    Google Scholar 

  88. Widimsky I, Fejfarova HM, Fejfar Z (1958) Der jugendliche Hochdruck. Arch Kreislauiforsch 28: 100

    Article  CAS  Google Scholar 

  89. Wigle ED, Felderhof CH, Silver MD, Abelman AG (1973) Hypertrophie obstructive cardiomyopathy. In: Fowler NO (ed) Myocardial Diseases. Grüne & Stratton, New York, London, pp 297–318

    Google Scholar 

  90. Wood P (1968) Diseases of the Heart and Circulation, 3rd ed. Eyre X XXX Spottiswode, London

    Google Scholar 

  91. World Health Organisation (1959) Hypertension and coronary heart disease: Classification and criteria for epidemiological studies. First report of the expert committee on cardiovascular diseases and hypertension. Techn Rep Ser 168

    Google Scholar 

  92. World Health Organization (1962) Arterial hypertension and ischemic heart disease, preventive aspects. Report of an expert committee. Techn Rep Ser 231

    Google Scholar 

  93. Handbook of Physiology (1968) Section 2: Circulation. American Physiological Society, Washington, D.C.

    Google Scholar 

  94. Gumming GR, Proudfit WL (1959) High voltage QRS complexes in the absence of left ventricular hypertrophy. Girculation 19: 406

    Google Scholar 

  95. Goldberger E (1953) Unipolar Lead Electrocardiography and Vectorcardiography, 3rd ed. Lea X XXX Febiger, Philadelphia

    Google Scholar 

  96. Grant RP (1957) The Spatial Vector Approach: Clinical Electrocardiography. McGraw-Hill, New York

    Google Scholar 

  97. Gubner R, Ungerleider HE (1942) Electrocardiographic criteria of left ventricular hypertrophy. Arch Int Med 72: 196

    Google Scholar 

  98. Hain P, von Mengden HJ, Just H (1978) Beziehungen von elektrokardiographischen und vektorkardio- graphischen Parametern mit angiographisch ermittelten Massen linker Ventrikel bei Patienten mit Linksherzbelastung. Verh Dtsch Ges Inn Med 84: 657

    PubMed  Google Scholar 

  99. Lamb LE (1965) Electrocardiography and Vectorcardiography. Saunders, Philadelphia

    Google Scholar 

  100. Mazzoleni A, Wolif R, Wolff L, Reiner L (1964) Correlation between component cardiac weights and electrocardiographic patterns in 185 cases. Circulation 30: 808

    PubMed  CAS  Google Scholar 

  101. von Mengden HJ, Just H, Brodda K, Wellner U, Hain P (1978) Electrophysiological interpretation of spatial VCG-parameters in left ventricular hypertrophy and left bundle branch block. In: Antaloczy Z (ed) Modern Electrocardiology. Excerpta Medica, Amsterdam, p 349

    Google Scholar 

  102. Morris JJ Jr, Estes HE, Whalen RE, Thompson HK, Mcintosh HD (1964) P-wave analysis in valvular heart disease. Circulation 29: 242

    PubMed  Google Scholar 

  103. Noth PH, Myers GB, Klein HA (1947) Precordial electrocardiogram in left ventricular hypertrophy. Lab Clin wmed 32: 1517

    Google Scholar 

  104. Csapo G (1980) Konventionelle und intrakardiale Elektrokardiographie. Documenta, Geigy

    Google Scholar 

  105. Sokolow M, Lyon TP (1949) The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. Am Heart 37: 161

    Article  CAS  Google Scholar 

  106. Thomas P, Dejong T (1952) The P-wave in the electrocardiogram in the diagnosis of heart disease. Brit Heart 16: 241

    Article  Google Scholar 

  107. Wikstrand J, Wallentin I, Hartford M, Berglund G (1980) The corrected (orthogonal) ECG in the early diagnosis of the influence of hypertension on the heart. Electromedica 3: 87

    Google Scholar 

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Just, H., Strauer, B.E. (1982). Central Hemodynamics and Cardiac Function in Hypertension. In: Rosenthal, J. (eds) Arterial Hypertension. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5657-1_18

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  • DOI: https://doi.org/10.1007/978-1-4612-5657-1_18

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