Pathogenesis of High Altitude Pulmonary Edema (HAPE)

  • R. Viswanathan
Conference paper
Part of the Topics in Environmental Physiology and Medicine book series (TEPHY)


Changes in physiologic functioning in high altitude environment are primarily due to the effect of low oxygen pressure and cold. Of these two hypoxic environment is the most important. Some of the acute effects of high altitude exposure which have been observed are pulmonary hypertension, coronary dilatation with normal blood flow, hyperventilation and consequent alkalosis, and polycythemia. Pulmonary hypertension is the most relevant to the pathogenesis of HAPE.


Hypoxic Stress Cold Pressor Test Coronary Dilatation Plasma Histamine Level High Altitude Environment 
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© Springer-Verlag New York, Inc. 1982

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  • R. Viswanathan

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