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Solubilization, Purification and Properties of Membrane-Bound Brain Enzymes which Biosynthesize Phosphoinositides

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Book cover Neural Membranes

Part of the book series: Experimental and Clinical Neuroscience ((ECN))

Abstract

For some years, evidence has steadily accumulated that cellular inositol phospholipid metabolism is stimulated in response to hormones or neurotransmitters in a variety of tissues. These are now generally considered to be receptor-mediated, cyclic AMP-independent phenomena which involve an initial accelerated breakdown of one or more of the phosphoinositides followed by their resynthesis. The nature of the molecular linkage between receptor activation, stimulated phosphoinositide degradation and subsequent cellular events, such as mobilization of cytosolic Ca 2+ or liberation of arachidonic acid as precursor to prostaglandin formation, has become a significant problem in membrane biochemistry and is discussed in another chapter in this volume (Hauser 1983).

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Authors and Affiliations

  1. Department of Biochemical and Biophysical Sciences, University of Houston, Houston, TX, 77004, USA

    Joseph Eichberg, J. Robert Bostwick & Abdallah Ghalayini

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  1. Joseph Eichberg
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  2. J. Robert Bostwick
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  3. Abdallah Ghalayini
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Editor information

Grace Y. Sun Nicolas Bazan Jang-Yen Wu Guiseppe Porcellati Albert Y. Sun

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© 1983 The Humana Press Inc.

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Eichberg, J., Bostwick, J.R., Ghalayini, A. (1983). Solubilization, Purification and Properties of Membrane-Bound Brain Enzymes which Biosynthesize Phosphoinositides. In: Sun, G.Y., Bazan, N., Wu, JY., Porcellati, G., Sun, A.Y. (eds) Neural Membranes. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-5636-6_9

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  • DOI: https://doi.org/10.1007/978-1-4612-5636-6_9

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-5638-0

  • Online ISBN: 978-1-4612-5636-6

  • eBook Packages: Springer Book Archive

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