Abstract
A single seizure promotes the accumulation of free fatty acids (FFA), especially arachidonic, stearic, docosahexaenoic, palmitic, and oleic acids, in the central nervous system (Bazan, 1970: Bazan and Rakowski, 1970). The stimulation of deacylation pathways of excitable membrane phospholipids and the decreased ability to activate- reacylate the released acyl groups leads to a transient accumulation of FFA (Bazan, 1970: Bazan and Rakowski, 1970:Rodriguez de Turco et al., 1977). Diglycerides (DG) also are accumulated and display a fatty acid composition similar to the FFA (Aveldano and Bazan, 1979). Electroconvulsive shock (Bazan, 1970: Bazan and Rakowski, 1970), pentylenetetrazol (Cenedella et al., 1975) and bicuculline (Seisjo et al., 1982: Rodriguez de Turco et al., 1983: Bazan et al., 1982b) are some of the convulsive-producing treatments that have been found to increase brain FFA. It seems that although hypoxia (Porcellati et al., 1978) ischemia (Bazan, 1970, 1971a, 1976; Galli and Spagnuolo, 1976; Bazan et al., 1971, 1982; Kuwashima et al., 1978; Majewska et al., 1981; Aveldano and Bazan, 1978) yield lipid effects that are similar to those seen with induced seizure activity, hypoxia is not involved during seizures inasmuch as the same effect was seen when experiments were performed on well-oxygenated and paralyzed animals (Seisjo et al., 1982).
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Bazan, N.G., Morelli de Liberti, S.G., Rodriguez de Turco, E.B., Pediconi, M.F. (1983). Free Arachidonic and Docosahexaenoic Acid Accumulation in the Central Nervous System During Stimulation. In: Sun, G.Y., Bazan, N., Wu, JY., Porcellati, G., Sun, A.Y. (eds) Neural Membranes. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-5636-6_5
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