Abstract
Since the proposal of the fluid mosaic model of membrane structure by Singer and Nicolson (1972), new research interests were initiated towards understanding the structure and functions of biological membrane. Modern biochemical and biophysical techniques have been developed for probing the membrane properties, and through these studies, unique features of membrane topography have been revealed. Indeed, we are only beginning to realize the complexity of the structural organization of biomembranes and the intricate metabolic relationships among the membrane components. Consequently, the modern concept of biological membrane has evolved from what used to be a simple lipid bilayer structure to include more detailed considerations such as presence of pools, hydrophobicity, charges, channels, pores, asymmetry and microenvironment.
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References
Aeberhard, EE, Gan-Elepano, M and Mead, JF (1981) Metabolism of fatty acids in rat brain membranes. Lipids 16, 705–713
Asimakis, GK and Sordahl, LA (1 977) Effects of atractyloside and palmitoyl coenzyme A on calcium transport in cardiac mitochondria., Arch. Biochem. Biophys. 179, 200-210.
Baker, RR and Thompson, W (1 973) Selective acylation of 1-acylglycerophosphorylino sitol by rat brain microsomes., Comparison with lacylglycerophosphorylcholine., J. Biol. Chem. 248, 7060–7065.
Baker, RR, Dowdall, MJ and Whittaker, VP (1975) The involvement of lysophosphoglyc- erides in neurotransmitter release: composition and turnover of phospholipids of synaptic vesicles of guinea pig cerebral cortex and Torpedo electric organ and the effect of stimulation. Brain Res. 100, 629–644.
Bazan, NG (1970) Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochim. Biophys. Acta 218, 1–10.
Bazan, NG (1976) Free arachidonic acid and other lipids in the nervous system during early ischemia and after electroshock. In: Function and Metabolism of Phospholipids in the Central and Peripheral Nervous Systems ( Porcellati, G, Amaducci, L and Galli, C, eds.) pp. 317–335, Plenum Press, New York.
Asimakis, GK and Sordahl, LA (1 977) Effects of atractyloside and palmitoyl coenzyme A on calcium transport in cardiac mitochondria., Arch. Biochem. Biophys. 179, 200–210.
Bjerve, KS, Daae, LNW and Bremer, J (1974) The selective loss of lysophospholipids in some commonly used lipid-extraction procedures., Anal. Biochem. 58, 238–245.
Blaustein, MP, Johnson, EM and Needleman, P (1972) Calcium dependent norepinephrine release from presynaptic nerve endings in vitro, Proc. Natl. Acad. Sci. 69, 2237–2240.
Chan, PH and Fishman, RA (1 978) Brain edema: induction in cortical slices by polyunsaturated fatty acids. Science 201, 358–360.
Chan, PH and Fishman, RA (1980) Transient formation of superoxide radicals in polyunsaturated fatty acids-induced brain swelling., J. Neurochem. 35, 1004–1007.
Chan, PH and Fishman, RA (1 982) Alterations of membrane integrity and cellular constituents by arachidonic acid in neuroblastoma and glioma cells., Brain Res. 248, 151–157.
Chan, PH and Fishman, RA (1983) Phospholipid degradation and the early release of polyunsaturated fatty acids in the evolution of brain edema. 5th Int. Symp. on Brain Edema, (in press)
Cooper, MF and Webster, GR (1 970) The differentiation of phospholipase A1 and A2 in rat and human nervous tissues. J. Neurochem. 17, 1543–1554.
Cooper, MF and Webster, GR (1 972) On the pho spholipase A2 activity of human cerebral cortex. J. Neurochem. 19, 333–340.
Corbin, DR and Sun, GY (1 978) Characteriza-tion of the enzymic transfer of arachidonoyl groups to 1-acyl-phosphoglycerides in mouse synaptosome fraction., J. Neurochem. 30, 77–82.
DeLorenzo, RJ (1982) Calmodulin in neurotrans-mitter release and synaptic function. Fed. Proc. 41, 2265–2272
De Medio, GE, Goracci, G, Horrocks, LA, Lazarewicz, JW, Mazzari, S, Porcellati, G, Strosznajder, J and Trovarelli, G (1980) The effect of transient ischemia on fatty acid and lipid metabolism in the gerbil brain. Ital. J. Biochem. 29, 412–432.
Foster, RE, Kocsis, JD, Malenka, RC and Waxman, SG (1980) Lysophosphatidylcholine-induced focal demyelination in the rabbit corpus callosum., J. Neurol. Sci. 48, 221–231
Cooper, MF and Webster, GR (1 972) On the pho spholipase A2 activity of human cerebral cortex. J. Neurochem. 19, 333–340.
Gan-Elepano, M, Aeberhard, E and Mead, JF (1981) On the mechanisms of fatty acid transformations in membranes. Lipids 16, 790–795.
Gray, NCc and Strickland, KP (1 982) On the specificity of a phospholipase A2 purified from the 106 ,000 x g pellet of bovine brain. Lipids 17, 91–96.
Hallett, DW (1981) A sensitive enzymic assay for lysolecithin. Thesis, University of Missouri-Columbia
Houslay, MD and Palmer, RW (1979) Lysophos-phatidylcholines can modulate the activity of the glucagon-stimulated adenylated cyclase from rat liver plasma membranes. Biochem. J. 178, 217–221.
Howell, JI and Lucy, JA (1969) Cell fusion induced by lysolecithin., FEBS Lett. 4, 147–150
Katz, AM, Messineo, F, Miceli, J and Nash-Adler, PA (1981) Low concentrations of fatty acids can inhibit calcium efflux from sarcoplasmic reticulum vesicles. Life Sci. 28, 1103–1107
Lazarewicz, J, Leu, V, Sun, GY and Sun, AY (1983) Arachidonic acid release from K+- evoked depolarization of brain synaptosomes. Neurochem. Int. (in press)
Leibovitz-BenGershon, Z, Kobiler, H and Gatt, S (1972) Lysophospholipases of rat brain. J. Biol. Chem. 247, 6840–6817
Majewska, MD, Manning, R and Sun, GY (1981) Effects of postdecapitative ischemia on arachidonate release from brain synaptosomes. Neurochem. Res. 6, 567–576.
Majewska, MD and Sun, GY (1 982) Activation of arachidonoyl-phosphatidylinositol and phos-phatidylcholine turnover by K+-evoked stimulation of brain synaptosomes., Neurochem. Int. 4, 427–433.
Moskowitz, N, Schook, W and Puszkin, S (1982) Interaction of brain synaptic vesicles induced by endogenous Ca2+-dependent phospholipase A2. Science 216, 305–307
Mulder, AH, van den Berg, WB and Stoot, JG (1975) Calcium-dependent release of radio-labeled catecholamines and serotonin from rat brain synaptosomes in a superfusion system. Brain Res. 99, 41 9–429
Pichard, AL and Cheung, WY (1977) Cyclic 3’:5’-nucleotide phosphodiesterase. Stimulation of bovine brain cytoplasmic enzyme by lysophosphatidylcholine., J. Biol. Chem. 252, 4872–4875.
Rhoads, DE, Kaplan, MA, Peterson, NA and Raghupathy, E (1982) Effects of free fatty acids on synaptosomal amino acid uptake systems. J. Neurochem. 38, 1255–1260.
Rotman, A (1977) The effect of phospholipase C, phospholipase A2 and neuraminidase on the uptake of [3H]2 norepinephrine and [3H] serotonin by rat brain synaptosomes. J. Neurochem. 28, 1369–1372.
Seisjo, BK, Martin Ingvar, and Westerberg, E (1982) The influence of bicuculline-induced seizures on free fatty acid concentrations in cerebral cortex, hippocampus, and cerebellum. J. Neurochem. 39, 796–802
Serhan, CN, Fridovich, J, Goetzl, EJ, Dunham, PB and Weissmann, G (1982) Leukotriene B2 and phosphatidic acid are calcium ionophores. Studies employing arsenazo III in liposomes. J. Biol. Chem. 257, 4746–4752
Shier, WT (1977) Inhibition of acyl-CoA: lysolecithin acyltransferases by local anesthetics, detergents and inhibitors of cyclic nucleotide phosphodiesterases., Biochem. Biophys. Res. Commun. 75, 186–193.
Shier, WT, Baldwin, JH, Nilsen-Hamilton, M, Hamilton, RT and Thanassi, NM (1976) Regulation of guanylate and adenylate cyclase activities by lysolecithin., Proc. Natl. Acad. Sci. USA 73, 1586–1590.
Shiu, GK, Nemoto, EM and Alexander, HL (1981) Brain free fatty acid changes during global ischemia with barbiturate anesthesia and hypothermia., Brit. J. Anaesthesia 53, 304.
Singer, SJ and Nicolson, GL (1972) The fluid mosaic model of the structure of cell membranes. Science 175, 720–724.
Strosznjder, J, Tang, W, Manning, R, Lin, AYT, MacQuarrie, R and Sun, GY (1981) Metabolism of oleoyl-CoA in rat brain synaptosomes: Effects of calcium and post-decapitative ischemia. Neurochem. Res. 6, 1231–1240
Sun, AY and Sun, GY (1976) Functional roles of phospholipids of synaptosomal membrane., In: Function and Metabolism of Phospholipids in the Central and Peripheral Nervous Systems ( Porcellati, G, Amaducci, L and Galli, C, eds.) pp. 169–197 ) Plenum Press, New York.
Sun, GY (1973) The turnover of phosphoglycerides in the subcellular fractions of mouse brain. A study using [14C] -oleic acid as precursor., J. Neurochem. 21, 1083–1092.
Sun, GY (1982) Metabolic turnover of arachidonoyl groups in brain membrane phosphoglycerides. In: Phospholipid Metabolism in the Nervous System, Metabolism (Horrocks, LA, Ansell, GB, and Porcellati, G, eds.) Vol. 1, PP. 75–89, Raven Press, New York
Sun, GY and Horrocks, LA (1973) The metabolism of palmitic acid in the subcellular fractions of mouse brain. J. Lipid Res. 14, 206–214.
Sun, GY and Su, KL (1979) Metabolism of arachidonoyl phosphoglycerides in mouse brain subcellular fractions. J. Neurochem. 32, 1053–1059.
Sun, GY, Corbin, DR, Wise, RW and MacQuarrie, R (1979a) Effects of lipid intermediates, lyso-glycerophospholipids and detergents on arachidonate transfer to 1- acyl-glycerophospholipids by brain synapto-somes. Int. J. Biochem. 10, 557–563.
Sun, GY, Su, KL, Der, OM and Tang, W (1979b) Enzymic regulation of arachidonate metabolism in brain membrane phosphoglyc-erides. Lipids 14, 229–235
Sun, GY, Tang, W and Sun, AY (1 982) Changes in free fatty acids and diacylglycerols in rat brain due to acute ethanol administration., Fed. Proc. 41, 4270
Sundler, R, Duzgunes, N and Papahadjopoulos, D (1981) Control of membrane fusion by phospholipid head groups. II. The role of phosphatidylethanolamine in mixtures with phosphatidate and phosphatidylinositol. Biochim. Biophys. Acta 649, 751–758.
Tang, W and Sun, GY (1982) Factors affecting the free fatty acids in rat brain cortex. Neurochem. Int. 4, 269–273.
Van den Bosch, H (1980) Intracellular phospholipase A. Biochim. Biophys. Acta 604, 191–246.
Van den Bosch, H and van den Besselaar, AMHP (1978) Intracellular formation and removal of lysophospholipids. In: Advances in Prosta-glandin and Thromboxane Research ( Galli, C et al., eds.) Vol. 3, pp. 69–75, Raven Press, New York
Vignais, PV, Lauquin, GJM and Vignais, PM (1976) In: Mitochondria. (Packer, L and Gomez-Puyon, A, eds.) pp. 109–125, Academic Press, New York
Webster, GR (1973) Phospholipase A activites in normal and sectioned rat sciatic nerve., J. Neurochem. 21, 873–876.
Webster, GR and Alpern, RJ (1964) Studies on the acylation of lysolecithin by rat brain., Biochem. J. 90, 35–41.
Webster, GR and Cooper, M. (1968) On the site of action of phosphatide acylhydrolase activity of rat brain homogenates on lecithin. J. Neurochem. 15, 795–802
Weltzien, HU (1979) Cytolytic and membrane-perturbing properties of lysophosphatidylcholine., Biochim.Biophys. Acta 559, 259–287
Woelk, H, Kanig, K and Peiler-Ichikawa, K (1974a) Phospholipid metabolism in experimental allergic encephalomyelitis: activity of mitochondrial phospholipase A2 of rat brain towards specifically labelled 1, 2-diacyl-1-alk-1 ’-enyl-2-acyl- and 1-alkyl-2- aoyl-sn-glycer o-3-phosphorylcholine., J. Neurochem. 23, 745–750.
Woelk, H, Peiler-Ichikawa, K, Binaglia, L, Goracci, G and Porcellati, G (1974b) Distribution and properties of phospholipases A1 and A2 in synaptosomes and subsynaptosomal fractions of rat brain. Hoppe Seyler’s Z. Physiol. Chem. 355, 1535–1542
Woelk, H, Ariente, G, Gaiti, A., Kanig, K and Porcellati, G (1981) Action of phospholipase A2 of rabbit neuronal and glial cells on 1, 2-diacyl-, 2-acy1-1-alk-1eny 1-, and 2-acyl-1- alky1-glycerophosphatides. Neurochem. Res. 6, 23–32
Wojtezak, L (1976) Effect of long-chain fatty acid and acyl-CoA on mitochondrial permeability, transport, and energy coupling process. J. Bioenerg. Biomemb. 8, 293–311.
Wood, JM, Bush, B, Pitts, BJR and Schwartz, A (1977) Inhibition of bovine heart Na+,K+- ATPase by palmitylcarnitine and palmityl-CoA. Biochem. Biophys. Res. Commun. 74, 677–684.
Zimmerberg, J, Cohen, FS and Finkelstein, A (1980) Micromolar Ca++ stimulates fusion of lipid vesicles with planar bilayers containing a calciumbinding protein. Science 210, 906–908.
Zwiller, J, Cresielski-Treska, J and Mandel, P (1976) Effect of lysolecithin on guanylate and adenylate cyclase activities in neuroblastoma cells in culture. FEBS Lett. 69, 286–290
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Sun, G.Y., Tang, W., Majewska, M.D., Hallett, D.W., Foudin, L., Huang, S. (1983). Involvement of Phospholipid Metabolites in Neuronal Membrane Functions. In: Sun, G.Y., Bazan, N., Wu, JY., Porcellati, G., Sun, A.Y. (eds) Neural Membranes. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-5636-6_3
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DOI: https://doi.org/10.1007/978-1-4612-5636-6_3
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