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Roles of Synaptic Membranous Phospholipids in the Modulation of Cerebral GABA and Benzodiazepine Receptor Bindings

  • Kinya Kuriyama
  • Yukio Yoneda
Part of the Experimental and Clinical Neuroscience book series (ECN)

Abstract

It has been well established that ϒ-aminobutyric acid (GABA) plays an inhibitory neurotransmitter role in the mammalian central nervous system (CNS) (Kuriyama et al., 1966: Iversen and Bloom, 1972: Yoneda and Kuriyama, 1978) as well as in the invertebrate nervous system (Kravitz et al., 1965). The specific binding of [3H] GABA to synaptic membrane preparations obtained from the rat brain has been thought to reflect the association of this neuroactive amino acid with its physiologically relevant synaptic receptors (Zukin et al., 1974: Enna and Snyder, 1977). Recently, it has been also demonstrated that muscimol, which is isolated from the mushroom Amanita muscaria, has a potent agonistic action on synaptic GABA receptors (Krogsgaard-Larsen et al., 1976), and [3H] muscimol is usable as a specific radioligand for biochemical (Beaumont et al., 1978; Snodgrass, 1978) as well as autoradiographic (Chan-Palay, 1979) studies on GABA receptors in the mammalian CNS. In addition, muscimol is known to be a more potent agonist than GABA itself in terms of the Induction of conductance changes at the crustacean inhibitory synapses (Hori et al., 1978)

Keywords

Gaba Receptor Synaptic Membrane Mammalian Central Nervous System Diazepam Binding Fatty Acid Anion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1983

Authors and Affiliations

  • Kinya Kuriyama
    • 1
  • Yukio Yoneda
    • 1
  1. 1.Department of PharmacologyKyoto Prefectural University of MedicineKyotoJapan

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