Ir Genes pp 553-563 | Cite as

Identification of H-2-Restricted Suppressor T Cell Factors Specific for L-Glutamic Acid50-L-Tyrosine50(GT) and L-Glutamic Acid60-L-Alanine30-L-Tyrosine10(GAT)

  • Judith A. Kapp
  • Barbara A. Araneo
  • Craig M. Sorensen
  • Carl W. Pierce
Part of the Experimental Biology and Medicine book series (EBAM, volume 4)


The synthetic polymers GAT and GT are closely related antigens that stimulate responses regulated by genes in the I region of the H-2 gene complex. The responses stimulated by these two antigens are distinct and the genetics of the regulation of the immune responses are different. First, some mice (H-2a,b,d,k) produce antibody and develop T cell proliferative responses to GAT while others (H-2p,q,s) do not (1–4); whereas, none of the inbred strains of mice tested produce antibody or develop proliferative responses to GT (5,6). All mice produce specific antibody and are primed for T cell proliferative responses to GAT or GT when immunized with GAT or GT complexed to methylated bovine serum albumin (MBSA). Second, GAT stimulates specific suppressor T cells in all non-responder strains (7,8), whereas GT stimulates suppression in some (H-2k,d,s), but not other (H-2a,b,q) nonresponder mice (9,10). Production of GAT specific suppressor T cells is not limited to nonresponder strains of mice, since similar T cells have been detected in adult responder strains of mice that were injected intravenously with GAT or GAT-pulsed macrophages (GAT-Mø) as neonates (11).


Spleen Cell Suppressive Activity Sheep Erythrocyte Suppressor Factor Cell Proliferative Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© The Humana Press Inc. 1983

Authors and Affiliations

  • Judith A. Kapp
    • 1
  • Barbara A. Araneo
    • 1
  • Craig M. Sorensen
    • 1
  • Carl W. Pierce
    • 1
  1. 1.Departments of Pathology and Laboratory MedicineThe Jewish Hospital of St. LouisSt. LouisUSA

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