Ir Genes pp 425-431 | Cite as

Ia Antigens as Restriction Molecules in Ir-Gene Controlled T-Cell Proliferation

  • Z. A. Nagy
  • Z. Ikezawa
  • M. Marušić
  • C. N. Baxevanis
  • N. Ishii
  • J. Klein
Part of the Experimental Biology and Medicine book series (EBAM, volume 4)


Restriction molecules involved in proliferative T-cell response were determined by blocking of the responses with monoclonal antibodies specific for either A (AαAβ) or E (EαEβ) molecules. Non-Ir-gene controlled responses to a large number of antigens were found to be channelled through both A and E molecules. In contrast, responses under Ir-gene control were always restricted to one of the two class II molecules (either A or E), and the class II context of recognition of a given antigen remained the same in all (or almost all) responder haplotypes. This remarkable consistency in channelling of the response to a given antigen via either A or E molecules is termed selective restriction. Selective restriction seems to operate also in the generation of suppressor T cells: thus far, we have found three Ir-gene controlled responses, in which recognition of the antigen together with E (but not A) molecules leads to Ts-cell generation.


Lactate Titration Myeloma Fibrinogen Sonal 


A molecule

Encoded by the A α and A β loci in the I-A region


Antigen presenting cell


Bovine insulin


Complete Freund’s adjuvant


Chorionic gonadotropin



E molecule

Encoded by the Eβ locus in the I-A and the locus in the I-E region.


Follicle stimulating hormone


Poly (Glu60Ala30Tyrl0)


Poly (Glu51Lys34Tyrl5)


Poly (Glu50Tyr50)


Lactate dehydrogenase B


Major histocompatibility complex


Stimulation index


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Copyright information

© The Humana Press Inc. 1983

Authors and Affiliations

  • Z. A. Nagy
    • 1
  • Z. Ikezawa
    • 1
  • M. Marušić
    • 1
  • C. N. Baxevanis
    • 1
  • N. Ishii
    • 1
  • J. Klein
    • 1
  1. 1.Abt. ImmungenetikMax-Planck-Institut für BiologieTübingenFederal Republic of Germany

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