Ia Antigens as Restriction Molecules in Ir-Gene Controlled T-Cell Proliferation
Restriction molecules involved in proliferative T-cell response were determined by blocking of the responses with monoclonal antibodies specific for either A (AαAβ) or E (EαEβ) molecules. Non-Ir-gene controlled responses to a large number of antigens were found to be channelled through both A and E molecules. In contrast, responses under Ir-gene control were always restricted to one of the two class II molecules (either A or E), and the class II context of recognition of a given antigen remained the same in all (or almost all) responder haplotypes. This remarkable consistency in channelling of the response to a given antigen via either A or E molecules is termed selective restriction. Selective restriction seems to operate also in the generation of suppressor T cells: thus far, we have found three Ir-gene controlled responses, in which recognition of the antigen together with E (but not A) molecules leads to Ts-cell generation.
KeywordsSelective Restriction Monoclonal Antibody Antibody Enzyme Alcohol Dehydrogenase Maximal Percent Inhibition Restriction Molecule
- A molecule
Encoded by the A α and A β loci in the I-A region
Antigen presenting cell
Complete Freund’s adjuvant
- E molecule
Encoded by the Eβ locus in the I-A and the locus in the I-E region.
Follicle stimulating hormone
Lactate dehydrogenase B
Major histocompatibility complex
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