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Ir Genes pp 425-431 | Cite as

Ia Antigens as Restriction Molecules in Ir-Gene Controlled T-Cell Proliferation

  • Z. A. Nagy
  • Z. Ikezawa
  • M. Marušić
  • C. N. Baxevanis
  • N. Ishii
  • J. Klein
Part of the Experimental Biology and Medicine book series (EBAM, volume 4)

Abstract

Restriction molecules involved in proliferative T-cell response were determined by blocking of the responses with monoclonal antibodies specific for either A (AαAβ) or E (EαEβ) molecules. Non-Ir-gene controlled responses to a large number of antigens were found to be channelled through both A and E molecules. In contrast, responses under Ir-gene control were always restricted to one of the two class II molecules (either A or E), and the class II context of recognition of a given antigen remained the same in all (or almost all) responder haplotypes. This remarkable consistency in channelling of the response to a given antigen via either A or E molecules is termed selective restriction. Selective restriction seems to operate also in the generation of suppressor T cells: thus far, we have found three Ir-gene controlled responses, in which recognition of the antigen together with E (but not A) molecules leads to Ts-cell generation.

Keywords

Selective Restriction Monoclonal Antibody Antibody Enzyme Alcohol Dehydrogenase Maximal Percent Inhibition Restriction Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

A molecule

Encoded by the A α and A β loci in the I-A region

APC

Antigen presenting cell

BI

Bovine insulin

CFA

Complete Freund’s adjuvant

CGT

Chorionic gonadotropin

DNAse

Deoxyribonuclease

E molecule

Encoded by the Eβ locus in the I-A and the locus in the I-E region.

FSH

Follicle stimulating hormone

GAT

Poly (Glu60Ala30Tyrl0)

GLT

Poly (Glu51Lys34Tyrl5)

GT

Poly (Glu50Tyr50)

LDHB

Lactate dehydrogenase B

Mhc

Major histocompatibility complex

S.I.

Stimulation index

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Copyright information

© The Humana Press Inc. 1983

Authors and Affiliations

  • Z. A. Nagy
    • 1
  • Z. Ikezawa
    • 1
  • M. Marušić
    • 1
  • C. N. Baxevanis
    • 1
  • N. Ishii
    • 1
  • J. Klein
    • 1
  1. 1.Abt. ImmungenetikMax-Planck-Institut für BiologieTübingenFederal Republic of Germany

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