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Ir Genes pp 355-359 | Cite as

H-2-Linked IR Gene Control of H-2 Unrestricted Cytotoxic T Lymphocytes

  • Jo-Ann Keene
  • James Forman
Part of the Experimental Biology and Medicine book series (EBAM, volume 4)

Abstract

The ability to generate H-2 unrestricted cytotoxic T lymphocytes (CTL) in vitro to the Qa-1b alloantigen following in vivo priming is under immune response (IR) gene control. B6.Tlaa mice lack the dominant IR gene and therefore cannot generate anti-Qa-1b CTL when immunised with Qa-1 congenic cells from B6 mice. A and (B6.Tla x A)F1 animals do respond to Qa-1 when immunized with congenic A.Tlab or (B6 x A) F1 cells, respectively. Segregation analysis indicates that the ability to respond is linked to the H-2 gene complex. The lack of the IR gene(s) does not represent a CTL repertoire defect because anti-Qa-1 CTL precursors (CTL.P) exist in the B6.Tla mice and can be activated if Qa-1b is presented together with helper determinants during the in vivo priming. Recognition of helper determinants need not occur during in vitro culture. Therefore, an H-2 linked IR gene controls the ability of animals to recognize helper determinants in vivo, a process requisite for the generation of CTL from unprimed CTL precursors.

Keywords

Immune Response Gene Helper Activity Helper Determinant Dominant Immune Response Immunology Program 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1983

Authors and Affiliations

  • Jo-Ann Keene
    • 1
  • James Forman
    • 1
  1. 1.Department of Microbiology and Immunology ProgramUTHSCDDallasUSA

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