Abstract
The human chromosome 6 contains a cluster of genes known as the major histocompatibility complex (MHC) which encode a number of cell surface glycoproteins involved in various immune interactions (1,2). The HLA-A, -B, and -C glycoproteins are called class I antigens or transplantation antigens, and HLA-D(R) class II antigens. Class I antigens are expressed on almost all types of cells and consist of a heavy chain of molecular weight 45,000 daltons noncovalently associated with P2 microglobulin, a protein of molecular weight about 12,000 daltons. Class II antigens have limited tissue distribution and are predominantly expressed on ‘B’ lymphocytes. Class II antigens consist of a heavy chain of molecular weight 34,000 daltons (p34) noncovalently bound to a light chain of molecular weight 29,000 daltons (p29). The p34 chain has very limited polymorphism, whereas the p29 chain varies substantially from individual to individual (3–6). Thus, the polymorphism of HLA-D(R) is mainly due to the p29 polypeptide.
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Das, H.K., Biro, P.A., Mullis, C., Lawrance, S.K., Weissman, S.M. (1983). The Cloning and Structure of the Heavy Chain Gene of HLA-D(R). In: Pierce, C.W., Cullen, S.E., Kapp, J.A., Schwartz, B.D., Shreffler, D.C. (eds) Ir Genes. Experimental Biology and Medicine, vol 4. Humana Press. https://doi.org/10.1007/978-1-4612-5633-5_34
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DOI: https://doi.org/10.1007/978-1-4612-5633-5_34
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