Special Aspects of Childhood Sarcomas
Soft-tissue sarcomas in infants and children are unusual tumors, representing the fourth most common malignant disease in patients under 15 years of age (Table 13-1) (42). They represent a significant percentage of the solid neoplasms arising in children and frequently present both diagnostic and therapeutic dilemmas. In recent years a great deal of interest has centered on the marked improvement in disease control that has resulted from combined-modality treatment of rhabdomyosarcomas. Other forms of soft-tissue sarcoma arising in childhood are much less common, less is known, about their natural history, and combined-modality therapy trials for these lesions are nonexistent. This chapter will review the sarcomas arising in childhood and the differences when compared with adult sarcomas. The main thrust of this chapter will be the discussion of the emerging data on rhabdomyosarcomas.
KeywordsSynovial Sarcoma Smooth Muscle Tumor Embryonal Rhabdomyosarcoma Nonoperative Therapy Malignant Schwannoma
Unable to display preview. Download preview PDF.
- 7.Dehner LP, Askin FB: Tumors of fibrous tissue origin in childhood: a clinicopatho- logic study of cutaneous and soft tissue neoplasms in 66 children. Cancer 38:888–900, 1976.Google Scholar
- 9.Exelby PR, Knapper WH, Huvos AG, Beattie EJ: Soft-tissue fibrosarcoma in children. J Pediatr Surg 8:415; 20, 1973.Google Scholar
- 20.Lawrence W Jr, Hays DM: Surgical lessons from the Intergroup Rhabdomyosarcoma Study. J Natl Cancer Inst 56: 159 – 163, 1981.Google Scholar
- 25.Maurer HM, Donaldson M, Gehan EA, Hammond D, Hays DM, Lawrence W Jr, Lindberg R, Newton W, Ragab A, Raney RB, Ruymann F, Soule EH, Sutow WW, Tefft M (for the IRS Committee): The Intergroup Rhabdomyosarcoma Study: Update—November, 1978. Natl Cancer Inst Monogr 56: 61 – 68, 1981.Google Scholar
- 27.Neifeld JP, Berg JW, Godwin D, Salzberg AM: A retrospective epidemiologic study of pediatric soft tissue sarcomas. Presented at the Annual Meeting of the American Academy of Pediatrics, October 1980.Google Scholar
- 29.Nelson AJ III: Embryonal rhabdomyosarcoma. Report of 24 cases and study of the effectiveness of radiation therapy upon the primary tumor. Cancer 22:64–68, 1968.Google Scholar
- 32.Raney RB, Hays DM, Lawrence W, Soule EH, Tefft M, Donaldson MH (for the IRS Committee): Paratesticular rhabdomyosarcoma in childhood. Cancer 42: 729 – 736, 1978.Google Scholar
- 33.Raney RB Jr, Tefft M, Maurer HM, Newton WA, Ragab AH, Lawrence W Jr, Foulkes MA: Results of intensive treatment of children with cranial paramenin- geal sarcoma: a report from the Intergroup Rhabdomyosarcoma Study. Proc AACR 23:120, 1982 (abst.)Google Scholar
- 35.Soule EH, Mahour GH, Mills SD, Lynn HB: Soft-tissue sarcomas of infants and children: a clinicopathologic study of 135 cases. Mayo Clinic Proc 43:313–326, 1968.Google Scholar
- 38.Sulamaa M, Moller C: Soft tissue sarcoma in children. J Pediatr Surg 4:520–525, 1969.Google Scholar
- 40.Tefft M, Hays D, Raney RB, Lawrence W, Soule E, Donaldson M, Sutow WW, Gehan E (for the IRS Committee): Radiation to regional nodes for rhabdomyosarcoma of the genitourinary tract in children: Is it necessary? A report of the Intergroup Rhabdomyosarcoma Study #1 (IRS-I). Cancer 45: 3065 – 3068, 1980.Google Scholar