A New Class of 5α-Reductase Inhibitors
Over the past 20 years several approaches to the control of androgen action have been investigated by research teams at Merck & Co., Inc. Basically, these approaches can be described as those that would cause chemical interference at certain critical stages where hormone development or action takes place (Fig. 1). These studies were initiated largely through the efforts of the late Dr. Glen E. Arth, the Steroid Chemistry group leader in the Department of Synthetic Chemical Research (1957–1975).
KeywordsAndrogen Receptor Seminal Vesicle Cyproterone Acetate Ventral Prostate Testosterone Propionate
Unable to display preview. Download preview PDF.
- Ham EA, Kuehl FA, Arth GE, unpublished resultsGoogle Scholar
- Johnston DBR, Schmitt SM, Arth GE, Brooks JR, Berman C, Primka RL, unpublished resultsGoogle Scholar
- Liao S (1977) In: Litwick G (ed) Biochemical Actions of Hormones. Academic Press, New York, pp 351–406Google Scholar
- Liao S, Liang T, Fang S, Castaneda E, Shao T-C (1973) J Biol Chem 248: 6156Google Scholar
- Milgrom E (1978) In: O’Malley WO, Birnbaumer L (eds) Receptors and Hormone Action. Vol II, Academic Press, New York, pp 473–490Google Scholar
- Neumann F, von Berswordt-Wallrabe R, Elger W, Steinbeck H, Hahn JD, Kramer M (1969) Recent Prog Horm Res 26: 337Google Scholar
- Nozu K, Tamaoki B-I (1974) Biochim Biophy Acta 348: 321Google Scholar