A New Class of 5α-Reductase Inhibitors
Over the past 20 years several approaches to the control of androgen action have been investigated by research teams at Merck & Co., Inc. Basically, these approaches can be described as those that would cause chemical interference at certain critical stages where hormone development or action takes place (Fig. 1). These studies were initiated largely through the efforts of the late Dr. Glen E. Arth, the Steroid Chemistry group leader in the Department of Synthetic Chemical Research (1957–1975).
KeywordsEstrogen Cortisol Histamine Hydride Charcoal
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