Abstract
The frequency of bladder outlet obstructive symptoms in Caucasion men over age 50 approaches 50–75%,29 and microscopic cellular hyperplasia resulting from a second prostatic growth spurt14 may be documented in 75% of men by age 90.3 The inconsistent relationship between degree of prostatic hyperplasia and development of symptoms6 has been related to fibroadenomatous nodule formation resulting from periurethral mesenchymal stimulation interacting with epithelial proliferation.7 McNeal14 described a “transition zone” of perisphincter tissue that may represent a specific site of origin of benign prostatic hypertrophy (BPH) (Fig. 1).
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Tannenbaum, S.I., Paulson, D.F. (1983). Effect of Hormones on Established Prostatic Hypertrophy. In: Hinman, F., Boyarsky, S. (eds) Benign Prostatic Hypertrophy. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5476-8_23
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DOI: https://doi.org/10.1007/978-1-4612-5476-8_23
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