The Relationship Between Benign Prostatic Hyperplasia and Prostatic Carcinoma

  • Clarence V. Hodges
  • Shaw P. Wan


The relationship between benign prostatic hyperplasia (BPH) and prostatic carcinoma (PC) has long been a subject of speculation and controversy. It is well known that BPH and PC frequently coexist in the same gland. Geraghty19 in 1922 studied a series of 450 prostatic carcinomas and noted a 75% association with hyperplasia. On the other hand, carcinoma has been incidentally found in 5–25% of prostates removed for benign hyperplasia.7,9,32


Prostatic Cancer Prostatic Carcinoma Prostate Gland Benign Prostatic Hyper Patient Radical Prostatectomy Specimen 
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  1. 1.
    Albarran J, Halle N: Hypertrophic et neoplasies epitheliales de la prostate. Ann Mai Org Urin 18:113–147, 225–261, 1900Google Scholar
  2. 2.
    Andrews GS: Latent carcinoma of the prostate. J Clin Pathol 2: 197–208, 1949CrossRefGoogle Scholar
  3. 3.
    Armenian HK, Lilienfeld AM, Diamond EL, Bross ID: Relationship between benign prostatic hyperplasia and cancer of the prostate. Lancet 2: 115–117, 1974PubMedCrossRefGoogle Scholar
  4. 4.
    Baron E, Angrist A: Incidence of occult carcinoma of the prostate after 50 years of age. Arch Pathol 32: 787, 1941Google Scholar
  5. 5.
    Bartsch W, Horst HJ, Becker H, Nehse G: Sex hormone binding globulin capacity, testosterone, 5-alpha, dihydrotestosterone, oestradiol, and pro lactin in plasma of patients with prostatic carcinoma under various types of hormonal treatment. Acta Endocrinol (Copenh) 85: 650–664, 1977Google Scholar
  6. 6.
    Bates HR Jr, Thornton JL: Carcinoma of prostatic ducts (letter). Am J Clin Pathol 45: 96, 1966PubMedGoogle Scholar
  7. 7.
    Bauer WC, McGravran MH, Carlin MR: Unsuspected carcinoma of the prostate in suprapubic prostatectomy specimens: a clinicopathological study of 55 consecutive cases. Cancer 13: 370–378, 1960PubMedCrossRefGoogle Scholar
  8. 8.
    Caine M: Late results and sequelae of prostatectomy. Br J Urol 26: 205–226, 1954PubMedCrossRefGoogle Scholar
  9. 9.
    Denton SE, Choz SH, Valk WL: Occult prostatic carcinoma diagnosed by the step-section technique of the surgical specimen. J Urol 93: 296–298, 1965PubMedGoogle Scholar
  10. 10.
    Dossot R: Cancer of the prostate: its origin and extension. J Urol 23: 217–245, 1930Google Scholar
  11. 11.
    Ende N, Woods LP, Shelley HS: Carcinoma originating in ducts surrounding the prostatic urethra. Am J Clin Pathol 40: 183–189, 1963PubMedGoogle Scholar
  12. 12.
    Fisher ER, Jeffrey W: Ultrastructure of human normal and neoplastic prostate; with comments relative to prostatic effects of hormonal stimulation in the rabbit. Am J Clin Pathol 44: 119–134, 1965PubMedGoogle Scholar
  13. Fraley EE, Ecker S: Tumor production in immune- suppressed hamsters by spontaneously transformed human prostatic epithelium. J Urol 30. 106: 95–99, 1971Google Scholar
  14. 14.
    Franks LM: Atrophy and hyperplasia in the prostate proper. J Pathol Bacteriol 68: 617–621, 1954PubMedCrossRefGoogle Scholar
  15. 15.
    Franks LM: Benign nodular hyperplasia of the 31. prostate: a review. Ann R Coll Surg 14: 92–106, 1954Google Scholar
  16. 16.
    Franks LM: Latent carcinoma of the prostate. J Pathol Bacteriol 68: 603–616, 1954PubMedCrossRefGoogle Scholar
  17. 17.
    Franks LM: The prostate. In Anderson WAD, Kissane JM (eds.): Pathology, 7th ed., Vol 1. Mosby, St. Louis, 1977, pp 999–1012Google Scholar
  18. 18.
    Gaeta JF, Berger JE, Gamarra MC: Scanning electron microscopic study of prostatic cancer. Cancer Treat Rep 61: 227–253, 1977PubMedGoogle Scholar
  19. 19.
    Geraghty JT: Treatment of malignant disease of the prostate and bladder. J Urol 7: 33–65, 1922Google Scholar
  20. 20.
    Greenwald P, Kirmss V, Polan AK, Dick VS: Cancer of the prostate among men with benign prostate hyperplasia. J Natl Cancer Inst 53: 335–340, 1974PubMedGoogle Scholar
  21. 21.
    Griffith K, Davies P, Harper ME, Peeling WB, Pierrepoint, CG: The etiology and endocrinology 36. of prostatic cancer. In Rose DP (ed.): Endocrinology of Cancer, Vol II. CRC Press, Boca Raton, 1979, pp 1–55.Google Scholar
  22. 22.
    Harbitz TB, Haugen OA: History of the prostate in elderly men. Acta Pathol Microbiol Scand [A] 38. 80: 756–768, 1972Google Scholar
  23. 23.
    Hirst AE Jr, Bergman RT: Carcinoma of the prostate in men 80 or more years old. Cancer 7: 136–141, 1954PubMedCrossRefGoogle Scholar
  24. 24.
    Huggins C, Clark PJ: Quantitative studies of prostate secretion. II. The effect of castration and of estrogen injection of the normal and of the hyperplastic prostate gland of dogs. J Exp Med 72:747– 762, 1940Google Scholar
  25. 25.
    Huggins C, Hodges CV: Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatase in metastatic carcinoma of the prostate. Cancer Res 1: 293–297, 1941Google Scholar
  26. 26.
    Huggins C, Masina MH, Eichelberger L, Wharton JD: Quantitative studies of prostatic secretion. I. Characteristics of the normal secretion: the influence of thyroid, suprarenal, and testis extirpation and androgen substitution on the prostatic output. J Exp Med 70: 543–556, 1939PubMedCrossRefGoogle Scholar
  27. 27.
    Huggins C, Stevens R, Hodges CV: Studies on prostatic cancer. II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg 43: 209–223, 1941Google Scholar
  28. 28.
    Johnson JA: Histological diagnosis and prognosis in patients operated upon for prostatic obstruction. Acta Clin Scand [Suppl] 286, 1962Google Scholar
  29. 29.Jones RE, Sanford EJ, Rohner TJ Jr, Rapp F: In vitro viral transformation of human prostatic carcinoma. J Urol 115: 82–85, 1976Google Scholar
  30. 30..
    Kirchheim D, Niles NR, Frankus E, Hodges CV: Correlative histochemical and histological studies on thirty radical prostatectomy specimens. Cancer 19: 1683–1696, 1966PubMedCrossRefGoogle Scholar
  31. 31.
    Krieg M, Grobe I, Voigt KD, Altenahr E, Klosterhalfen H: Human prostatic carcinoma: significant differences in its androgen binding and metabolism compared to the human benign prostatic hypertrophy. Acta Endocrinol (Copenh) 88: 397–07, 1978Google Scholar
  32. 32.
    Labess M: Occult carcinoma in clinically benign hypertrophy of the prostate: a pathological and clinical study. J Urol 68: 893–896, 1952PubMedGoogle Scholar
  33. 33.
    Marmorston J, Lombardo LJ, Myers SM, Gierson H, Stern E, Hopkins CE: Urinary excretion of neutral 17-ketosteroids and pregnanediol by patients with prostatic cancer and benign hypertrophy. J Urol 93: 276–295, 1965PubMedGoogle Scholar
  34. 34.
    McNeal JE: Morphogenesis of prostatic carcinoma. Cancer 18: 1659–1666, 1965PubMedCrossRefGoogle Scholar
  35. 35.
    McNeal JE: The anatomic heterogeneity of the prostate. Prog Clin Biol Res 37: 149–160, 1980PubMedGoogle Scholar
  36. 36.
    McNeal JE: The prostate and prostatic urethra: a morphologic synthesis. J Urol 107: 1008–1016, 1972PubMedGoogle Scholar
  37. 37.
    Moore RA: Benign hypertrophy of the prostate, a morphological study. J Urol 50: 680–710, 1943Google Scholar
  38. 38.
    Moore RA: Morphology of small prostatic carcinoma. J Urol 33: 224–234, 1935Google Scholar
  39. 39.
    Reischauer F: Die Entsehung der sogenannten Prostata hypertrophic. Zentralbl Chir 52: 517–520, 1925Google Scholar
  40. 40.
    Rich AR: On the frequency of occurrence of occult carcinoma of the prostate. J Urol 33: 215–223, 1935Google Scholar
  41. 41.
    Shaw EC: An early case of carcinoma of the prostate associated with benign hypertrophy. J Urol 11: 63–73, 1924Google Scholar
  42. 42.
    Siiteri PK, Wilson JD: Dihydrotestosterone in prostatic hypertrophy. I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man. J Clin Invest 49: 1737–1745, 1970PubMedCrossRefGoogle Scholar
  43. 43.
    Sinha A A, Blackard CE: Ultrastructure of prostatic benign hyperplasia and carcinoma. Urology 2: 114–120, 1973PubMedCrossRefGoogle Scholar
  44. 44.
    Sinha AA, Bentley MD, Blackard CE: Freeze-fracture observations on the membranes and junctions in human prostatic carcinoma and benign prostatic hypertrophy. Cancer 40: 1182–1188, 1977PubMedCrossRefGoogle Scholar
  45. 45.
    Tannenbaum M, Spiro D, Lattimer JK: Biology of the prostate gland: the electron microscopy of cytoplasmic filamentous bodies in human benign prostatic cells adjacent to cancerous cells. Cancer Res 27: 1415–1417, 1967PubMedGoogle Scholar
  46. 46.
    Tannenbaum M: Histopathology of the prostate gland. In Tannenbaum M (ed.): Urologie Pathology: The Prostate. Lea & Febiger, Philadelphia, 1977, pp 303–398Google Scholar
  47. 47.
    Ullmann AS, Ross OA: Hyperplasia, atypism, and carcinoma in situ in prostatic periurethral glands. Am J Clin Pathol 47: 497–504, 1967PubMedGoogle Scholar
  48. 48.
    Vital Statistics and Causes of Death. World Health Statistics Annual Report, Vol 1. World Health Organization, Geneva, 1971Google Scholar
  49. 49.
    White JW: The results of double castration in hypertrophy of the prostate. Ann Surg 22: 1–80, 1895PubMedCrossRefGoogle Scholar
  50. 50.
    Young HH, Davis DM: Young’s Practice of Urology, Vol 1. Saunders, Philadelphia, 1926, pp 613– 671Google Scholar

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© Springer-Verlag New York Inc. 1983

Authors and Affiliations

  • Clarence V. Hodges
  • Shaw P. Wan

There are no affiliations available

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