Abstract
As with much else in prostatic disease, the basic facts about benign enlargement have been known for many years but the major questions remain unanswered. Some of these problems are outlined here. Over 200 years ago Morgagni14 clearly de-scribed the site of origin of prostatic enlargement “in the very middle of the internal and upper circumference of the gland” and went on to say “but whether all these things happened by chance, or otherwise, future observations will show.” Unfortunately, future observations still leave room for considerable doubt about the precise nature of the glands from which the hyperplasia arises.12 Even the title of this volume, Benign Prostatic Hypertrophy, underlines the confusion; there is no doubt that the condition does not involve hypertrophy of any of the prostatic components, although of course secondary hypertrophy of the bladder is common.
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References
Chesterman FC, Franks LM, Williams PC: Effects of age, castration and stilboestrol treatment on the guinea pig prostate and associated structures. In Grayhack JT, Wilson JD, Scherbenske MJ (eds.): Benign Prostatic Hyperplasia. DHEW Publication No. (NIH)76-1113, US Gov’t Printing Office, Washington, DC, 1976, pp 223–234
Cunha GR: Epithelial-stromal interactions in development of the urogenital tract. Int Rev Cytol 47: 137–189, 1976
Cunha GR, Lung B: The importance of stroma in morphogenesis and functional activity of urogenital epithelium. In Vitro 15:50–71, 1979
Franks LM: Benign nodular hyperplasia of the prostate: a review. Ann R Coll Surg 14: 92–106, 1954
Franks LM: Benign prostatic hyperplasia: gross and microscopic anatomy. In Grayhack JT, Wilson JD, Scherbenske MJ (eds): Benign Prostatic Hyperplasia. DHEW Publication No. (NIH)76-1113, US Gov’t Printing Office, Washington, DC, 1976, pp 63–89
Franks LM: Latent carcinoma. Ann R Coll Surg 15: 236–249, 1954
Franks LM: Primary cultures of human prostate. Methods Cell Biol 21: 153–169, 1980
Franks LM, Barton AA: The effects of testosterone on the ultrastructure of the mouse prostate in vivo and in organ cultures. Exp Cell Res 19: 35–50, 1960
Heatfield BM, Sanefuji H, Trump BF: Long-term explant culture of normal human prostate. Methods Cell Biol 21: 171–194, 1980
Lechner JF, Babcock MS, Marnell M, Shankar Narayan K, Kaighn ME: Normal human prostate epithelial cell cultures. Methods Cell Biol 21: 195–225, 1980
Lowsley OS: The development of the human prostate gland with reference to the development of other structures at the neck of the urinary bladder. Am J Anat 13: 299–349, 1912
McNeal JE: Anatomy of the prostate: an historical survey of divergent views. Prostate 1: 3–13, 1980
McNeal JE: Regional morphology and pathology of the prostate. Am J Clin Pathol 49: 347–357, 1968
Morgagni G: The seats and causes of diseases investigated by anatomy. Johnson and Payne, London, 1769, pp 460–462
Reischauer F: Die Entstehung der sogenannten Prostatahypertrophie. Virchows Arch 256: 357–389, 1925
Zuckerman S, Groome JR: The aetiology of benign enlargement of the prostate in the dog. J Pathol Bacteriol 44: 113–124, 1937
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© 1983 Springer-Verlag New York Inc.
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Franks, L.M. (1983). Origins of Benign Prostatic Hypertrophy. In: Hinman, F., Boyarsky, S. (eds) Benign Prostatic Hypertrophy. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5476-8_13
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DOI: https://doi.org/10.1007/978-1-4612-5476-8_13
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-5478-2
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