Advertisement

5ht Involvement in Tryptamine Induced Behaviour in Mice

  • Jane Irons
  • C. M. Robinson
  • C. A. Marsden

Abstract

Several studies have shown that tryptamine (T) administered to rodents pretreated with an MAO inhibitor produces characteristic behaviour (e.g. Clineschmidt and Lotti 1974, Marsden and Curzon 1978, Luscombe et al 1982). Depletion of 5HT decreases this response indicating involvement of neuronal 5HT (Foldes and Costa 1975, Marsden and Curzon 1978). Other studies however have suggested T may act directly on 5HT receptors while another possibility is the existence of specific T receptors in brain (Kellar and Cascio 1982). Recent behavioural studies have supported the concept of distinct 5HT and T receptors; for example T infused into rat hypothalamus causes hyperthermia while 5HT produces hypothermia (Cox et al 1981). Alternatively T could modulate 5HT mediated transmission via an action at 5HT receptors (Jones and Boulton 1980). The present study investigated the behavioural effects of administered T in the mouse with a view to elucidating the role of endogenous 5HT and 5HT receptors in the response.

Keywords

Locomotor Activity Induce Behaviour Head Twitch Hypothalamic Slice Normal Diet Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Clineschmidt B V and Lotti V J (1974) Indoleamine antagonists: Relative potencies as inhibitors of tryptamine and 5-hydroxytryptophan evoked responses. Br.J.Pharmac. 50 311–313Google Scholar
  2. Cox B, Lee T F and Martin D (1981) Different hypothalamic receptors mediate 5-hydroxytryptamine and tryptamine- induced core temperature changes in the rat. Br.J.Pharmac. 72 477–482Google Scholar
  3. Foldes A and Costa E (1975) Relationship of brain monoamine and locomotor activity in rats. Biochem. Pharmac. 24 1617–1621CrossRefGoogle Scholar
  4. Jones R S G and Boulton A A (1980) Tryptamine and 5- hydroxytryptamine. Actions and interactions on cortical neurones in the rat. Life Sci. 27 1849–1856PubMedCrossRefGoogle Scholar
  5. Kellar K J and Cascio C S (1982) [3H]-Tryptamine: high affinity binding sites in rat brain. Eur. J.Pharmac. 78 475–478CrossRefGoogle Scholar
  6. Luscombe G, Jenner P and Marsden C D (1982) Tryptamine- induced myoclonus in guinea-pigs pretreated with a monoamine oxidase inhibitor indicates pre- and post-synaptic actions of tryptamine upon central indoleamine systems. Neuropharmacology 21 1257–1265PubMedCrossRefGoogle Scholar
  7. Marsden C A and Curzon G (1978) The contribution of tryptamine to the behavioural effects of L-tryptophan in tranyl- cypromine-treated rats. Psychopharmacology 57 71–76PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1984

Authors and Affiliations

  • Jane Irons
    • 1
  • C. M. Robinson
    • 1
  • C. A. Marsden
    • 1
  1. 1.Department of Physiology and Pharmacology Medical SchoolQueen’s Medical CentreNottinghamUK

Personalised recommendations