Abstract
During the past 15 years, many methods have been developed for the detection of the trace amines and their metabolites. The trace amines that have been studied include phenylethylamine (PE), meta- and para-tyramine (m-TA and p-TA), tryptamine (T), phenylethanolamine (PEOH), meta- and para-octopamine (m-OA and p-OA) and meta- and para-synephrine (m-Syn and p-Syn). The trace metabolites for which methods have been developed are phenylacetic acid (PAA), meta- and para-hydroxyphenylacetic acids (m-HPAA and p-HPAA), meta- and para-hydroxymandelic acids (m-HMA and p-HMA), and para-hydroxyphenylethanol (p-HPE). Although attempts have been made to extend chemical and bioassay procedures which were successful for determinations of catecholamines, of these procedures, spectrofluorimetric or radioenzymatic assays were of mixed success and appear to have fallen into disuse. By far the greater number, and apparently universally successful procedures, involve mass spectrometry.
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Durden, D.A. (1984). Quantification of Trace Amines and Their Metabolites by High Resolution or Metastable Analysis Using Double Focussing Mass Spectrometry. In: Boulton, A.A., Baker, G.B., Dewhurst, W.G., Sandler, M. (eds) Neurobiology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5312-9_3
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DOI: https://doi.org/10.1007/978-1-4612-5312-9_3
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