Degradation Kinetics by MAO of PEA Derivatives. A Model for the Molecular Basis of their Analgesic and Behavioral Effects?
The classical endogenous noncatecholic phenylethylamines, phenylethylamine (PEA), phenylethanolamine, p-tyramine and p-octopamine appear to be involved in peripheral and central nervous system synaptic transmission mechanisms (1,2). The physiological and pharmacological actions of PEA appear of particular importance as alterations in the metabolism of this amine has been postulated to contribute to the pathophysiology of a number of neuropsychiatric disorders (3–7), migraine (8,9) and diabetes (10). In order to better understand the molecular basis of PEA actions we have examined the relationship between the chemical structure, the analgesic activity and kinetic parameters of degradation by monoamine oxidase (MAO) of a series of monosubstituted derivatives of PEA.
KeywordsDopamine Schizophrenia Morphine Quinone Prolactin
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