Strategies of Translation

  • Odd Nygård
  • Peter Westermann

Abstract

I wish to remark on possible differences between, among other things, prokaryotic and eukaryotic ribosomes. In order to do so, I will introduce you to what I call a molecular strategy. This is a simple notion which can be made accessible with the help of a riddle. The riddle is: If errors of translation are to be avoided, why are there common mutant ribosomes that are more accurate than wild type ribosomes? One class of relevant bacterial mutants are those that are streptomycin resistant (rpsL). These have been shown to lower the missense frequencies in translation due to suppressor tRNA’s as well as those arising spontaneously. Why, then aren’t all bacterial ribosomes as accurate as some of the streptomycin resistant ones?

Keywords

Expense Streptomycin Cytosol Nucleoside Guanine 

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Copyright information

© The Human Press Inc. 1983

Authors and Affiliations

  • Odd Nygård
    • 1
  • Peter Westermann
    • 2
  1. 1.The Wenner-Gren InstituteUniversity of StockholmStockholmSweden
  2. 2.Central Institute of Molecular BiologyAcademy of Sciences of GDRBerlin-BuchGermany

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