I wish to remark on possible differences between, among other things, prokaryotic and eukaryotic ribosomes. In order to do so, I will introduce you to what I call a molecular strategy. This is a simple notion which can be made accessible with the help of a riddle. The riddle is: If errors of translation are to be avoided, why are there common mutant ribosomes that are more accurate than wild type ribosomes? One class of relevant bacterial mutants are those that are streptomycin resistant (rpsL). These have been shown to lower the missense frequencies in translation due to suppressor tRNA’s as well as those arising spontaneously. Why, then aren’t all bacterial ribosomes as accurate as some of the streptomycin resistant ones?
KeywordsExpense Streptomycin Cytosol Nucleoside Guanine
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