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Excitotoxins

  • Graham A. R. Johnston
Part of the Experimental and Clinical Neuroscience book series (ECN)

Abstract

The majority of neurones in the mammalian central nervous system are now known to use relatively simple amino acids as synaptic transmitters. The acidic amino acids L-glutamate and L-aspartate act as excitatory transmitters while the neutral amino acids 4-aminobutyric acid and glycine act as inhibitory transmitters. Many neurotoxins are structurally related to these amino acid transmitters and may act adversely of the synaptic receptors, transport carriers and metabolising enzymes associated with such transmitters (Johnston, 1974).

Keywords

Glutamic Acid Kainic Acid Baby Food Ibotenic Acid Simple Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press inc. 1983

Authors and Affiliations

  • Graham A. R. Johnston
    • 1
  1. 1.Department of PharmacologyUniversity of SydneyAustralia

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