Dietary Restriction and Biologic Variables
Dietary restriction has been shown to increase the life span of a variety of young growing laboratory animals (1). For example, this phenomenon has been reported in the following model systems: Tokophrya, Campanularia flexuosa, Daphnia sp., rotifers, Drosophila sp., and fish. In addition, a number of laboratory experiments have been carried out on rodents. It has been generally believed that nutritional manipulations that increase life span had to be imposed during early growth. This concept originated from the early work of Minot, who postulated that senescence follows the cessation of growth (2,3). Furthermore, Lansing indicated that aging in the rotifer involved the appearance of a cytoplasmic factor that coincided with the cessation of growth (4). However, recent studies have indicated that dietary restriction imposed in adult life was effective in increasing the life span of rotifers, Daphnia sp., rats, hamsters, and mice (11). In studies using both young growing and adult animals, dietary restriction has been brought about by: (a) reducing the daily dietary intake of a nutritionally adequate diet (one that supports maximal growth); (b) intermittently feeding a nutritionally adequate diet (eg, feeding every second, third, or fourth day); and (c) feeding ad libitum a diet containing insufficient amounts of protein to support maximal growth.
KeywordsSucrose Starch Corn Lymphoma Adenosine
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