It goes without saying that one cannot interpret abnormal findings in the skin until one, at least, is somewhat familiar with normal findings. Thus, a review of selected aspects of normal skin anatomy is a logical starting point.* The skin is the largest organ of the body, covering 1.5-2.0 square meters, and weighing several kilograms. It serves as the interface between the body and its environment. Thus, the skin may change in response either to the internal milieu or to external factors. Such changes can be observed both grossly or macroscopically and microscopically. The essence of dermatology is the correlation of these macroscopic and microscopic findings. Thus, some background in clinical dermatology is essential to the budding dermatopathologist. However, the thrust of this manual will be microscopic disease. To recognize cutaneous abnormalities under the microscope, one must be familiar with normal skin’s appearance.
KeywordsStratum Corneum Basal Lamina Sebaceous Gland Bullous Pemphigoid Dermal Papilla
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