Abstract
Virus infections in animals involve complex virus-host interactions in which various schemes of replication of the agent are pitted against a multitude of host-defense mechanisms. The immune system is the most effective of the antiviral host defenses and usually succeeds in eliminating pathogens after brief periods of infection. Failure to cure infection indicates a shift in favor of the virus and this involves either some novel mechanism of viral replication that eludes the immune system or a defect, often virus induced, in the immune system that interferes with antiviral functions. This review examines one mode of viral persistence in which normal replication of the agent can occur in the functionally competent immune environment. The basic mechanism of this process is mutation of the virus genome with attendant alteration in surface antigens, permitting escape from immune control.
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References
Bloom BR (1979) Games parasites play: how parasites evade immune surveillance. Nature 279:21–26
Webster RG, Laver WG, Air GM, Schild GC (1982) Molecular mechanisms of variation in influenza viruses. Nature 296:115–121
Wiktor TJ, Koprowski H (1980) Antigenic variants of rabies virus. J Exp Med 152:99–112
Ter Muelen V, Loffler S, Carter MJ, Stephenson JR (1981) Antigenic characterization of measles and SSPE virus haemmaglutinin by monoclonal antibodies. J Gen Virol 57:357–364
Kono Y, Kobayashi K, Fukunaga Y (1973) Antigenic drift of equine infectious anemia virus in chronically infected horses. Archiv Virusforchung 41:1–10
Narayan O, Griffin DE, Chase J (1977) Antigenic shift of visna virus in persistently infected sheep. Science 197:376–378
Narayan O, Griffin DE, Clements JE (1978) Virus mutation during “slow infection.” Temporal development and characterization of mutants of visna virus recovered from sheep. J Gen Virol 41:343–352
Narayan O, Clements JE, Griffin DE, Wolinsky JS (1981) Neutralizing antibody spectrum determines the antigenic profiles of emerging mutants of visna virus. Infect Immun 32:1045–1050
Clements JE, Petersen FS, Narayan O, Haseltine WS (1980) Genomic changes associated with antigenic variation of visna virus during persistent infection. Proc Natl Acad Sci USA 77:4454–4458
Clements JE, D’Antonio N, Narayan O (1982) Genomic changes associated with antigenic variation of visna virus. II. Common nucleotide changes detected in variants from independent isolations. J Mol Biol 158:415–434
Scott JV, Stowring L, Haase AT, Narayan O, Vigne R (1979) Antigenic variation in visna virus. Cell 18:321–327
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© 1984 Springer-Verlag New York Inc.
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Clements, J.E., Narayan, O. (1984). Immune Selection of Virus Variants. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5250-4_22
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DOI: https://doi.org/10.1007/978-1-4612-5250-4_22
Publisher Name: Springer, New York, NY
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