Utilization of Host Proteins as Virus Receptors

  • Gregory H. Tignor
  • Abigail L. Smith
  • Robert E. Shope

Abstract

A general construct in microbiology is that parasites and their hosts continuously evolve to ensure the survival of each. A significant portion of virologic research has been devoted to describing strategies used by different viruses to survive despite attempts by the host to prevent their replication. One hypothesis holds that virus attachment to host cell molecules unique to susceptible cells governs virus spread to, and infection of, specific target organs [1]. Our focus is on the implication of recent research developments that support this hypothesis. The observations have been made with viruses from diverse genera and with cells of different functional types. It may be overly simplistic to state that tissue tropisms are readily defined on the basis of attachment per se, but attachment is a logical starting point in studying the evolution of virus—host interactions, since it has been shown that both virus and host-cell receptors are genetically controlled [1,2]. An excellent review of general principles related to animal virus attachment has been written recently by Holmes [3]. A key issue in relating host-cell molecules to virus attachment is identification of the “productive receptor” [4]. This is the receptor that leads to infection rather than one that binds virus nonspecifically. Many enveloped viruses bind well to a number of nonproductive substrates including inanimate surfaces, such as polystyrene plates, which are not obviously related to tissue tropisms in vivo.

Keywords

Lymphoma Sarcoma Polypeptide Neurol Polystyrene 

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References

  1. 1.
    Crowell RL (1976) Comparative generic characteristics of picornavirus-receptor interactions. In Beers RF Jr, Bassett EG (eds) Cell Membrane Receptors for Viruses, Antigens and Antibodies, Polypeptide Hormones, and Small Molecules. Raven Press, New York, p 202Google Scholar
  2. 2.
    Green H (1974) The gene for the poliovirus receptor. N Engl J Med 290:1018–1019PubMedCrossRefGoogle Scholar
  3. 3.
    Holmes KV (1981) The biology and biochemistry of cellular receptors for enveloped viruses. In Lonberg-Holm K, Philipson L (eds) Virus Receptors. Part 2. Chapman and Hall, London, p 85Google Scholar
  4. 4.
    Dimmock NJ (1982) Initial stages in infection with animal viruses. J Gen Virol 59:1–22PubMedCrossRefGoogle Scholar
  5. 5.
    Piraino F (1967) The mechanism of genetic resistance of chick embryo cells to infection by Rous sarcoma virus (BS-RSV). Virology 32:700–707PubMedCrossRefGoogle Scholar
  6. 6.
    Crittenden LB (1968) Observations on the nature of a genetic resistance to avian tumor viruses. J Natl Cancer Inst 41:145–153PubMedGoogle Scholar
  7. 7.
    Weiss RA (1976) Receptors for RNA tumor viruses. In Beers RF Jr, Bassett EG (eds) Cell Membrane Receptors for Viruses, Antigens and Antibodies, Polypeptide Hormones, and Small Molecules. Raven Press, New York, p 237Google Scholar
  8. 8.
    Watson HD, Tignor GH, Smith AL (1981) Entry of rabies virus into the peripheral nerves of mice. J Gen Virol 56:371–382CrossRefGoogle Scholar
  9. 9.
    Lentz TL, Burrage TG, Smith AL, Crick J, Tignor GH (1982) Is the acetylcholine receptor a rabies virus receptor? Science 215:182–184PubMedCrossRefGoogle Scholar
  10. 10.
    Kristensson K (1978) Retrograde transport of macromolecules in axons. Ann Rev Pharmacol Toxicol 18:97–110CrossRefGoogle Scholar
  11. 11.
    Tignor GH, Shope RE, Bishop DHL, Smith AL, Burrage TG (1983) California serogroup gene structure-function relationships: Virulence and tissue tropisms. In Calisher CH (ed) California Serogroup Viruses. Alan R. Liss, New York, in pressGoogle Scholar
  12. 12.
    Smith AL (1978) In vitro characterization of host cell receptors in a Sindbis virus model of neuro virulence. Thesis, Yale University, New Haven, ConnecticutGoogle Scholar
  13. 13.
    Korn IL, Abramsky O (1981) Myasthenia gravis following viral infection. Eur Neurol 20:435–439PubMedCrossRefGoogle Scholar
  14. 14.
    Yefenof E, Klein G, Jondal M, Oldstone MB (1976) Surface markers on human B and T lymphocytes. IX. Two-color immunofluorescence studies on the association between EBV receptors and complement receptors on the surface of lymphoid cell lines. Int J Cancer 17:693–700PubMedCrossRefGoogle Scholar
  15. 15.
    Jondal M, Klein G, Oldstone MB, Bokish V, Yefenof E (1976) Surface markers on human B and T lymphocytes. VIII. Association between complement and Epstein-Barr virus receptors on human lymphoid cells. Scand J Immunol 5:401–410PubMedCrossRefGoogle Scholar
  16. 16.
    Volsky DJ, Shapiro IM, Klein G (1980) Transfer of Epstein-Barr virus receptors to receptor-negative cells permits virus penetration and antigen expression. Proc Natl Acad Sci USA 77:5453–5457PubMedCrossRefGoogle Scholar
  17. 17.
    Magrath I, Freeman C, Santaella M, Gadek J, Frank M, Spiegel R, Novikovs L (1981) Induction of complement receptor expression in cell lines derived from human undifferentiated lymphomas. II. Characterization of the induced complement receptors and demonstration of the simultaneous induction of EBV receptor. J Immunol 127:1039–1043PubMedGoogle Scholar
  18. 18.
    Hutt-Fletcher LM, Fowler E, Lambris JD, Feighny RJ, Simons JG, Ross GD (1983) Studies of the Epstein-Barr virus receptor found on Raji cells. II. A comparison of lymphocyte binding sites for Epstein-Barr virus and C3d. J Immunol 130:1309–1312PubMedGoogle Scholar
  19. 19.
    Sugden B (1982) Epstein-Barr virus: A human pathogen inducing lymphopro-liferation in vivo and in vitro. Rev Infect Dis 4:1048–1061PubMedCrossRefGoogle Scholar
  20. 20.
    Khelifa R and Menezes J (1983) Sendai virus envelopes can mediate Epstein-Barr virus binding to and penetration into Epstein-Barr virus-receptor negative cells. J Virol 46:325–332PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1984

Authors and Affiliations

  • Gregory H. Tignor
  • Abigail L. Smith
  • Robert E. Shope
    • 1
  1. 1.Yale University School of MedicineNew HavenUSA

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