Abstract
The basic neurocircuitry underlying the highest visual acuity pathways in such animals as birds, primates and certain reptiles (Cajal, 1933) is thought to consist of a bipolar cell/ganglion cell chain connected in a one to one fashion with a single cone photoreceptor. In the monkey retina, for example, there are midget bipolar cells and midget ganglion cells that subserve an individual cone (Polyak, 1941), In 1969 it was reported that the cone midget bipolar pathways of the rhesus monkey retina consisted of a pair of bipolars characterized by different types of synaptic contact with the cone pedicles in the outer plexiform layer (OPL) (Kolb et al., 1969). One of the midget bipolars inserted dendritic terminals into the synaptic complex of the cone pedicle to make “invaginating” contacts beneath the synaptic ribbon (Figures 1,2). The other midget bipolar, in contrast, made synaptic contacts with the surface of the cone pedicle on either side of the invaginating elements (Figures 1,3). In addition the two midget bipolar types were found to have different termination levels of their axons in the inner plexiform layer (IPL).
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References
Allen, R.A. (1969). The retinal bipolar cells and their synapses in the inner plexiform layer. In The retina: morphology, function and clinical characteristics. (eds. Straatsma, B.R., Hall, M.O., Allen, R.A. and Crescitelli, F.) pp. 101–143. Forum in Medical Sciences. No. 8 Berkeley: University of California Press.
Boycott, B.B. and Dowling, J.E. (1969). Organization of the primate retina: light microscopy. Phil. Trans. R. Soc. (Lond), B, 255: 109 – 184.
Boycott, B.B. and Kolb, H. (1973). The connections between the bipolar cells and photoreceptors in the retina of the domestic cat. J. Comp. Neur., 148: 91 – 114.
Boycott, B.B. and Wässle, H. (1974). The morphological types of ganglion cells of the domestic cat’s retina. J. Physiol. (Lond), 240: 397 – 419.
Cajal, S.R. (1933). Die Retina der Wirbeltiere. Wiesbaden: Bergmann; Trans. Thorpe, S.A. and Glickstein, M. (1972). The Structure of the Retina. Thomas, Springfield.
Cleland, B.G. and Levick, W.R. (1974a). Brisk and sluggish concentrically organized ganglion cells in the cat’s retina. J. Physiol. (Lond.), 240: 421 – 456.
Dowling, J.E. (1970). Organization of vertebrate retinas. Invest. Ophthal., 9: 655 – 680.
Dowling, J.E. and Werblin, F.S. (1969). Organization of the retina of the mudpuppy, Necturus maculosus. I. Synaptic structure, J. Neurophysiol., 32: 315 – 338.
Enroth-Cugell, C. and Robson, J.G. (1966). The contrast sensitivity of retinal ganglion cells of the cat. J. Physiol. (Lond.), 187: 517 – 552.
Famiglietti, E.V. and Kolb, H. (1975). A bistratified amacrine cell and synaptic circuitry in the inner plexiform layer of the retina. Brain Res. 84: 293 – 300.
Famiglietti, E.V. and Kolb, H. (1976). Structural basis for ‘ON’ and ‘OFF’-center responses in retinal ganglion cells. Science 194: 193 – 195.
Fukuda, Y. and Stone, J. (1974). Retinal distribution and central projections of Y-, X-, and W-cells of the cat’s retina. J. Neurophysiol., 37: 749 – 772.
Gouras, P. (1971). The function of the midget cell system in primate color vision. Vision Res. Suppl., 3: 397 – 410.
Ikeda, H. and Wright, M.J. (1972). Differential effects on refractive errors and receptive field organization of central and peripheral ganglion cells. Vision Res., 12: 1465 – 1476.
Ikeda, H. and Sheardown, M. (1983). Functional transmitters at retinal ganglion cells in the cat. Vision Res., 23: 1161 – 1174.
Kaneko, A. (1970). Physiological and morphological identification of horizontal, bipolar and amacrine cells in goldfish retina. J. Physiol. (Lond), 207: 623 – 633.
Kolb, H., Boycott, B.B. and Dowling, J.E. (1969). A second type of midget bipolar cell in the primate retina. Appendix. Phil Trans. R. Soc. (Lond.), B. 255: 177 – 184.
Kolb, H. (1970). Organization of the outer plexiform layer of the primate retina: electron microscopy of Golgi-impregnated cells. Phil. Trans. R. Soc. (Lond.), B, 258: 261 – 283.
Kolb, H. and Famiglietti, E.V. (1974). Rod and cone bipolar connections in the inner plexiform layer of the cat retina. Science 186: 47 – 49.
Kolb, H. (1979). The inner plexiform layer in the retina of the cat: electron microscope observations. J. Neurocytol., 8: 295 – 329.
Kolb, H. and Nelson, R. (1981). Three amacrine cells of the cat retina: morphology and intracellular responses. ARVO. Invest. Ophthal. Vis. Sci., Suppl., 20: p. 184.
Kolb, H., Nelson, R. and Mariani, A. (1981). Amacrine cells, bipolar cells and ganglion cells of the cat retina: a Golgi study. Vision Res., 21: 1081 – 1114.
Kolb, H. and Nelson, R. (1983). Rod pathways in the retina of the cat. Vision Res., 23: 301 – 312.
Kuffler, S.W. (1953). Discharge patterns and functional organization of mammalian retina. J. Neurophysiol., 16: 47 – 68.
Lasansky, A. (1978). Contacts between receptors and electrophysiologically identified neurones in the retina of the larval Tiger Salamander. J. Physiol. (Lond), 285: 531 – 542.
Leventhal, A.G., Keens, J. and Törk, I. (1980). The afferent ganglion cells and cortical projections of the retinal recipient zone (RRZ) of the cat’s ‘Pulvinar complex’. J. Comp. Neur., 194: 535 – 554.
Leventhal, A.G., Rodieck, R.W. and Dreher, B. (1981). Retinal ganglion cell classes in old world monkeys: morphology and central projections. Science 213: 1139 – 1142.
Leventhal, A.G. (1982). Morphology and distribution of retinal ganglion cells projecting to different layers of the dorsal lateral geniculate nucleus in normal and siamese cats. J. Neurosci., 2: 1024 – 1042.
Maguire, B.A., Stevens, J.K. and Sterling, P. (1982). “Push-pull” microcircuitry of the beta (X) ganglion cell in light adaptation. ARVO. Invest. Ophthal. Vis. Sci., Suppl. 22, p. 82.
Marchiafava, P.L. and Weiler, R. (1980). Intracellular analysis and structural correlates of the organization of inputs to ganglion cells in the retina of the turtle. Proc. R. Soc. (Lond.) B, 208: 103 – 113.
Mariani, A.P. (1981). A diffuse, invaginating cone bipolar cell in primate retina. J. Comp. Neur. 197: 661 – 671.
Mariani, A.P. (1982). Newly identified bipolar cells in monkey retina. ARVO. Invest. Ophthal. Vis. Sci. Suppl. 22, p. 247.
Marr, D. (1974). The computation of lightness by the primate retina. Vision Res. 14: 1377 – 1388.
Miller, R.F. (1980). The neuronal basis of ganglion-cell receptivefield organization and the physiology of amacrine cells. In Neuronal Interactions in the Vertebrate Retina. Neurosciences fourth study program, 1979 (Eds. Schmitt, F.O. and Worden, F.G.) MIT Press, Cambridge, MA and London, England.
Miller, R.F. and Dacheux, R.F. (1976). Synaptic organization and ionic basis on On and Off channels in mudpuppy retina. I. Intracellular analysis of chloride-sensitive electrogenic properties of receptors, horizontal cells, bipolar cells and amacrine cells. J. Gen. Physiol. 67: 639 – 659.
Naka, K-I. (1976). Neuronal circuitry in the cat fish retina. Invest. Ophthal., 15: 926 – 935.
Nelson, R. (1977). Cat cones have rod input: a comparison of the response properties of cones and horizontal cell bodies in the retina of the cat. J. Comp. Neur., 172: 109 – 135.
Nelson, R. (1980). Functional stratification of cone bipolar axons in the cat retina. ARVO. Invest. Ophthal. Vis. Sci., Suppl., p. 130.
Nelson, R. (1982). All amacrine cells quicken time course of rod signals in the cat retina. J. Neurophysiol. 47: 928 – 947.
Nelson, R., Famiglietti, E.V. and Kolb, H. (1978). Intracellular staining reveals different levels of stratification for on-center and off-center ganglion cells in the cat retina. J. Neurophysiol., 41: 472 – 483.
Nelson, R., Kolb, H., Famiglietti, E.V. and Gouras, P. (1976). Neural responses in rod and cone systems of the cat retina: Intracellular staining reveals different levels of stratification for on-center and off-center ganglion cells in the cat retina. J. Neurophysiol. 41: 472 – 483.
Nelson, R., Kolb, H., Robinson, M.M. and Mariani, A.P. (1981). Neural activity of the cat retina: cone pathways to ganglion cells. Vision Res. 21: 1527 – 1536.
Nelson, R. and Kolb, H. (1983). Synaptic patterns and response properties of bipolar and ganglion cells in the cat retina. Vision Res., 23: 1183 – 1195.
Ogden, T.E. (1974). The morphology of retinal neurons of the owl monkey, Aotes. J. Comp. Neur., 153: 399 – 428.
Polyak, S.L. (1941). The Retina. Univ. of Chicago Press.
Raviola, E. and Raviola, G. (1982). Structure of the synaptic membranes in the inner plexiform layer of the retina. A freeze-fracture study in monkeys and rabbits. J. Comp. Neur., 209: 233 – 248.
Steinberg, R.H., Reid, M. and Lacey, P.L. (1973). The distribution of rods and cones in the retina of the cat (Felis domesticus). J. Comp. Neur., 148: 229 – 248.
Sterling, P. (1983). Microcircuitry of the cat retina. Ann. Rev. in Neurosci., 6: 149 – 183.
Stevens, J.K., McGuire, B.A. and Sterling, P. (1980). Toward a functional architecture of the retina: serial reconstruction of adjacent ganglion eels. Science 207: 317 – 319.
Stone, J. (1965). A quantitative analysis of the distribution of ganglion cells in the cat’s retina: J. Comp. Neur. 124: 337 – 352.
Stone, LJ. and Hoffmann, K.P. (1972). Very slow-conduction ganglion cells in the cat’s retina: a major new functional type? Brain Res., 43: 610 – 616.
Toyoda, J-I. and Kujiraoka, T. (1982). Analysis of bipolar cell respones elicited by polarization of horizontal cells. J. Gen. Physiol. 79: 131 – 145.
Toyoda, J-I. and Fugimoto, M. (1983). Analyses of neural mechanisms mediating the effect of horizontal cells polarization. Vision Res., 23: 1143 – 1150.
Wässle, H., Peichl, L. and Boycott, B.B. (1981a). Morphology and topography of on- and off- alpha cells in the cat retina. Proc. R. Soc. (Lond.), B, 212: 157 – 175.
Wässle, H., Boycott, B.B. and Illing, R.-B. (1981b). Morphology and mosaic of on- and off- beta cells in the cat retina and some functional considerations. Proc. R. Soc. (Lond.), B, 212: 177 – 195.
Werblin, F.S. and Dowling, J.E. (1969). Organization of the retina of the mdpuppy, Necturus maculosus. II. Intracellular recording. J. Neurophysiol., 32: 339 – 355.
Yazulla, S. (1976). Cone input to bipolar cells in the turtle retina. Vision Res., 16: 737 – 744.
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Kolb, H. (1984). Cone Pathways in the Mammalian Retina. In: Hilfer, S.R., Sheffield, J.B. (eds) Molecular and Cellular Basis of Visual Acuity. Cell and Developmental Biology of the Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5236-8_4
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DOI: https://doi.org/10.1007/978-1-4612-5236-8_4
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