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Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia: Diagnosis and Treatment

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Diseases of the Lymphatic System

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Abstract

Chronic myelogenous leukemia (CML) is a primary disorder of the bone marrow that leads to expansion of the granulocytic series, less commonly the megakaryocytic series, and infrequently the erythroid cells. As a result of the expansion of the elements of each of these series, characteristic signs and symptoms occur (see below). The disease has two distinct phases: one, in which essentially “normal” differentiation occurs, can be readily controlled by many chemotherapeutic agents; and an acute phase, which usually results in limited survival and cannot be readily controlled. In general, the disease is associated with a specific chromosonal abnormality, and studies of this have lead to a greater understanding of how CML evolves. CML is distinguished easily from acute granulocytic leukemia when the former is in the chronic phase. However, it may be indistinguishable from the latter when the disease presents as an acute leukemia.2,61 This chapter is a review of the clinical characteristics of the disorder, the studies of the Philadelphia chromosome (Ph1) that yield information about the nature of the disease, and the therapeutic options that are currently available.

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  1. Zalmen A. Arlin
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Editors and Affiliations

  1. 235 East 67th Street, Suite 205, New York, NY, 10021, USA

    David W. Molander M.D. (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology) (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology)

  2. New York Hospital, New York City, USA

    David W. Molander M.D. (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology) (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology)

  3. Memorial Hospital, New York City, USA

    David W. Molander M.D. (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology) (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology)

  4. Cornell University College of Medicine, New York City, USA

    David W. Molander M.D. (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology) (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology)

  5. Tumor Board, Valley Hospital, Ridgewood, New Jersey, USA

    David W. Molander M.D. (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology) (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology)

  6. Tumor Board, Cape Cod Hospital, Hyannis, Massachusetts, USA

    David W. Molander M.D. (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology) (Assistant Attending Physician (Medicine), Associate Attending Physician (Hermatology/Lymphoma), Clinical Assistant Professor of Medicine, Consultant (Oncology)

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Arlin, Z.A. (1984). Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia: Diagnosis and Treatment. In: Molander, D.W. (eds) Diseases of the Lymphatic System. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5198-9_5

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