Left-Handed, Complementary Double Helices—A Heresy? The Z-DNA Family

  • Wolfram Saenger
Part of the Springer Advanced Texts in Chemistry book series (SATC)

Abstract

Guided by X-ray fiber diagrams of DNA and RNA double helices, molecular models with right-handed screw sense were developed. Because this experimental evidence cannot, per se, distinguish between image/mirror image or right/left-handed screw molecules, in the past serious doubts as to the DNA double-helical structure have been raised (107–114). Moreover, theoretical considerations suggested that the nucleotide unit in its standard conformation can be fitted into a left-handed double-helical screw with Watson-Crick-type base-pairing (380, 383). Only in recent years has the right-handed screw structure been fully supported by means of single-crystal X-ray studies on oligonucleotides (Sections 10.4, 11.2) and tRNA (Chapter 15).

Keywords

Sugar Oligomer Fluorene Sine Pyrimidine 

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Copyright information

© Springer-Verlag New York Inc. 1984

Authors and Affiliations

  • Wolfram Saenger
    • 1
  1. 1.Institut für KristallographieFreie UniversitätFederal Republic of Germany

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