Molecular Mechanisms of Drug Action and Pharmacokinetic-Pharmacodynamic Models

  • Wolfgang Sadée
Part of the Experimental Biology and Medicine book series (EBAM, volume 7)


Drug response triggered by receptor activation arises from a chain of events that are regulated by many factors. Molecular changes associated with drug sensitization or tolerance are currently being elucidated on the molecular level, e.g. for adenylate cyclase coupled systems. Despite the complexity of the drug-response mechanism, simple empirical pharmaco-dynamic models on the basis of the law of mass action are widely applicable to describe drug-effect relationships. In combination with a pharmacokinetic model and suitable delay functions, such models are capable of simulating the complete time course of drug action in vivo. The predictive potential of the pharmacokinetic-pharmacodynamic models should prove useful in evaluating pharmaceutical formulations with controlled drug delivery.


Adenylate Cyclase Receptor Occupancy Opiate Receptor Effect Compartment Coupling Protein 
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Copyright information

© The Humana Press Inc. 1985

Authors and Affiliations

  • Wolfgang Sadée
    • 1
  1. 1.School of PharmacyUniversity of CaliforniaSan FranciscoUSA

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